9IVP | pdb_00009ivp

24-mer DARPin-apoferritin scaffold in complex with the maltose binding protein

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	DARPin,Ferritin heavy chain, N-terminally processed	molecular sequestering activity iron ion sequestering activity metal ion sequestering activity cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding ferric iron binding oxidoreductase activity, acting on metal ions oxidoreductase activity molecular sequestering activity iron ion sequestering activity metal ion sequestering activity cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding ferric iron binding oxidoreductase activity, acting on metal ions oxidoreductase activity ferroxidase activity oxidoreductase activity, acting on metal ions, oxygen as acceptor catalytic activity identical protein binding protein binding	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis localization transport iron ion transport transition metal ion transport intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis localization transport iron ion transport transition metal ion transport monoatomic ion transport monoatomic cation transport establishment of localization metal ion transport response to stimulus immune response immune system process negative regulation of ferroptosis regulation of biological process regulation of cellular process negative regulation of programmed cell death biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of cellular process cellular process regulation of ferroptosis ferroptosis programmed cell death negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation fibroblast proliferation regulation of fibroblast proliferation negative regulation of fibroblast proliferation	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle vacuole autophagosome tertiary granule lumen tertiary granule autolysosome lytic vacuole secondary lysosome lysosome ferritin complex protein-containing complex nucleus
B, BA [auth CA], D, DA [auth EA], F, B, BA [auth CA], D, DA [auth EA], F, FA [auth GA], H, HA [auth IA], J, JA [auth KA], L, LA [auth MA], N, NA [auth OA], P, PA [auth QA], R, RA [auth SA], T, TA [auth UA], V [auth W], VA [auth WA], X [auth Y], Z [auth AA]	Maltodextrin-binding protein	transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding	localization transport carbohydrate transport oligosaccharide transport disaccharide transport establishment of localization maltose transport polysaccharide localization dextrin transport macromolecule localization maltodextrin transmembrane transport polysaccharide transport	ATPase dependent transmembrane transport complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex outer membrane-bounded periplasmic space cell envelope ATPase dependent transmembrane transport complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex outer membrane-bounded periplasmic space cell envelope periplasmic space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	IPR009040	Ferritin-like diiron domain	Domain
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	IPR012347	Ferritin-like	Homologous Superfamily
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	IPR009078	Ferritin-like superfamily	Homologous Superfamily
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	IPR008331	Ferritin/DPS domain	Domain
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	IPR001519	Ferritin	Family
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	IPR014034	Ferritin, conserved site	Conserved Site
B, BA [auth CA], D, DA [auth EA], F, B, BA [auth CA], D, DA [auth EA], F, FA [auth GA], H, HA [auth IA], J, JA [auth KA], L, LA [auth MA], N, NA [auth OA], P, PA [auth QA], R, RA [auth SA], T, TA [auth UA], V [auth W], VA [auth WA], X [auth Y], Z [auth AA]	IPR006060	Maltose/Cyclodextrin ABC transporter, substrate-binding protein	Family
B, BA [auth CA], D, DA [auth EA], F, B, BA [auth CA], D, DA [auth EA], F, FA [auth GA], H, HA [auth IA], J, JA [auth KA], L, LA [auth MA], N, NA [auth OA], P, PA [auth QA], R, RA [auth SA], T, TA [auth UA], V [auth W], VA [auth WA], X [auth Y], Z [auth AA]	IPR006059	Bacterial-type extracellular solute-binding protein	Family
B, BA [auth CA], D, DA [auth EA], F, B, BA [auth CA], D, DA [auth EA], F, FA [auth GA], H, HA [auth IA], J, JA [auth KA], L, LA [auth MA], N, NA [auth OA], P, PA [auth QA], R, RA [auth SA], T, TA [auth UA], V [auth W], VA [auth WA], X [auth Y], Z [auth AA]	IPR006061	Solute-binding family 1, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, AA [auth BA], C, CA [auth DA], E, A, AA [auth BA], C, CA [auth DA], E, EA [auth FA], G, GA [auth HA], I, IA [auth JA], K, KA [auth LA], M, MA [auth NA], O, OA [auth PA], Q, QA [auth RA], S, SA [auth TA], U [auth V], UA [auth VA], W [auth X], Y [auth Z]	Pharos: P02794	hemochromatosis type 5 malignant glioma malignant mesothelioma melancholia contact dermatitis Iron Overload mixed glioma keloid endogenous depression neurodegenerative disease non-small cell lung carcinoma asthma precancerous condition subependymal giant cell astrocytoma glioma hemochromatosis type 5 malignant glioma malignant mesothelioma melancholia contact dermatitis Iron Overload mixed glioma keloid endogenous depression neurodegenerative disease non-small cell lung carcinoma asthma precancerous condition subependymal giant cell astrocytoma glioma lung cancer ovarian cancer atypical teratoid rhabdoid tumor ulcerative colitis dermatomyositis lymphoplasmacytic lymphoma medulloblastoma neurotic disorder plasma cell myeloma psoriasis depressive disorder hepatocellular carcinoma large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.