9JVV | pdb_00009jvv

Overall structure of human EAAT2 in the substrate-free state

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00375	Sodium:dicarboxylate symporter family (SDF)	Sodium:dicarboxylate symporter family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Excitatory amino acid transporter 2	L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity acidic amino acid transmembrane transporter activity L-glutamate transmembrane transporter activity transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity sulfur amino acid transmembrane transporter activity sulfur compound transmembrane transporter activity neutral L-amino acid transmembrane transporter activity cysteine transmembrane transporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity acidic amino acid transmembrane transporter activity L-glutamate transmembrane transporter activity transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity sulfur amino acid transmembrane transporter activity sulfur compound transmembrane transporter activity neutral L-amino acid transmembrane transporter activity cysteine transmembrane transporter activity monoatomic cation transmembrane transporter activity amino acid:sodium symporter activity solute:sodium symporter activity solute:monoatomic cation symporter activity secondary active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity amino acid:monoatomic cation symporter activity high-affinity L-glutamate transmembrane transporter activity glutamate:sodium symporter activity sodium ion transmembrane transporter activity organic acid:sodium symporter activity active transmembrane transporter activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity symporter activity monoatomic anion transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding	localization transport neurotransmitter transport establishment of localization response to acid chemical response to stimulus response to chemical response to amino acid response to xenobiotic stimulus organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport localization transport neurotransmitter transport establishment of localization response to acid chemical response to stimulus response to chemical response to amino acid response to xenobiotic stimulus organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport amino acid transmembrane transport L-amino acid transport L-glutamate import organic acid transport transmembrane transport amino acid transport acidic amino acid transport dicarboxylic acid transport L-alpha-amino acid transmembrane transport cellular process L-glutamate transmembrane transport glutathione metabolic process modified amino acid biosynthetic process modified amino acid metabolic process amide biosynthetic process sulfur compound biosynthetic process biosynthetic process peptide biosynthetic process glutathione biosynthetic process metabolic process sulfur compound metabolic process amide metabolic process nonribosomal peptide biosynthetic process peptide metabolic process monoatomic ion transport behavior adult behavior multicellular organismal process import into cell aspartate transmembrane transport import across plasma membrane C4-dicarboxylate transport D-amino acid transport D-aspartate transmembrane transport D-aspartate import across plasma membrane amino acid import across plasma membrane response to light stimulus visual behavior response to radiation response to abiotic stimulus L-aspartate transmembrane transport transepithelial transport cellular localization establishment of localization in cell neurotransmitter uptake neurotransmitter reuptake L-aspartate import across plasma membrane L-glutamate import across plasma membrane developmental process head development forebrain development animal organ development brain development nervous system development multicellular organism development central nervous system development anatomical structure development telencephalon development system development response to stress response to wounding cellular response to nitrogen compound cellular response to stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to alkaloid cellular response to chemical stimulus cellular response to cocaine cellular response to alkaloid response to cocaine trans-synaptic signaling synaptic signaling regulation of biological process signaling anterograde trans-synaptic signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication protein-containing complex organization protein trimerization cellular component organization cellular component biogenesis cellular component assembly protein homotrimerization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular component organization or biogenesis system process circulatory system process vascular process in circulatory system vascular transport transport across blood-brain barrier regulation of localization hexose transmembrane transport D-glucose import regulation of cellular process positive regulation of biological process carbohydrate transport positive regulation of D-glucose transmembrane transport positive regulation of transmembrane transport positive regulation of cellular process regulation of D-glucose import positive regulation of D-glucose import regulation of transport regulation of transmembrane transport positive regulation of transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport multicellular organism growth developmental growth growth	protein-containing complex cellular anatomical structure membrane membrane protein complex membrane-bounded organelle organelle vesicle glial cell projection cell projection plasma membrane bounded cell projection astrocyte projection cell surface cell periphery plasma membrane protein-containing complex cellular anatomical structure membrane membrane protein complex membrane-bounded organelle organelle vesicle glial cell projection cell projection plasma membrane bounded cell projection astrocyte projection cell surface cell periphery plasma membrane presynapse synapse cell junction presynaptic membrane plasma membrane region synaptic membrane membrane microdomain membrane raft glutamatergic synapse neuron projection terminus neuron projection axon cell leading edge axolemma leading edge membrane neuron projection membrane main axon cell projection membrane cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR018107	Sodium:dicarboxylate symporter, conserved site	Conserved Site
A, B, C	IPR050746	Dicarboxylate/Amino Acid:Cation Symporter	Family
A, B, C	IPR036458	Sodium:dicarboxylate symporter superfamily	Homologous Superfamily
A, B, C	IPR001991	Sodium:dicarboxylate symporter	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P43004	epilepsy amyotrophic lateral sclerosis developmental and epileptic encephalopathy, 41 Nerve Degeneration cocaine abuse cocaine dependence gastric carcinoma Hashimoto thyroiditis large cell medulloblastoma malignant glioma adrenal cortex carcinoma medulloblastoma atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma bipolar disorder epilepsy amyotrophic lateral sclerosis developmental and epileptic encephalopathy, 41 Nerve Degeneration cocaine abuse cocaine dependence gastric carcinoma Hashimoto thyroiditis large cell medulloblastoma malignant glioma adrenal cortex carcinoma medulloblastoma atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma bipolar disorder pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor toxic encephalopathy essential tremor gastric neoplasm hereditary diffuse gastric adenocarcinoma lung carcinoma neurodegenerative disease pancreatic intraductal papillary-mucinous carcinoma Pick disease depressive disorder progressive supranuclear palsy type 2 diabetes mellitus gastric cancer glioblastoma hypothyroidism malignant ependymoma malignant pancreatic neoplasm astrocytic tumor oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma schizophrenia vitiligo

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.