9KDG | pdb_00009kdg

CryoEM structure of Calcineurin-fusion Human endothelin receptor type-B in the ligand-free form

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Calcineurin-fusion endothelin receptor type-B	-	-	-
B [auth F]	Peptidyl-prolyl cis-trans isomerase FKBP1B	protein binding binding signaling receptor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity RNA polymerase II CTD heptapeptide repeat P6 isomerase activity FK506 binding amide binding macrolide binding protein binding binding signaling receptor binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat peptidyl-prolyl isomerase activity RNA polymerase II CTD heptapeptide repeat P6 isomerase activity FK506 binding amide binding macrolide binding calcium channel activity monoatomic cation transmembrane transporter activity channel regulator activity monoatomic ion channel activity ion channel regulator activity calcium channel regulator activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity molecular function regulator activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transporter regulator activity transmembrane transporter activity RNA polymerase II CTD heptapeptide repeat P3 isomerase activity nucleoside phosphate binding cyclic nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding transmembrane transporter binding molecular function inhibitor activity transporter inhibitor activity calcium channel inhibitor activity channel inhibitor activity ion channel inhibitor activity	cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular response to stimulus multicellular organismal process regulation of cellular process response to stimulus cell projection organization positive regulation of neuron projection regeneration regulation of cellular response to stress neuron projection development regeneration neuron projection regeneration positive regulation of developmental process multicellular organism development neuron differentiation cell differentiation anatomical structure development positive regulation of cell projection organization response to wounding system development positive regulation of response to wounding developmental process regulation of biological process regulation of axon regeneration regulation of cell projection organization response to external stimulus nervous system development generation of neurons regulation of response to stimulus regulation of neuron projection regeneration regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization regulation of developmental process cellular developmental process regulation of response to external stimulus positive regulation of biological process cell development response to axon injury regulation of response to wounding positive regulation of response to stimulus cellular component organization neurogenesis positive regulation of response to external stimulus cellular response to stress axon regeneration positive regulation of neuron projection development regulation of response to stress response to stress cellular component organization or biogenesis positive regulation of cellular process plasma membrane bounded cell projection organization biological regulation axon development neuron development cellular process positive regulation of axon regeneration regulation of plasma membrane bounded cell projection organization protein refolding primary metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process metabolic process protein metabolic process macromolecule metabolic process positive regulation of cytosolic calcium ion concentration regulation of biological quality regulation of calcium ion transport regulation of localization intracellular calcium ion homeostasis negative regulation of biological process negative regulation of transport calcium ion transport localization negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis transport homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion negative regulation of calcium ion transport cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport response to redox state sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum system process smooth muscle contraction muscle contraction muscle system process signaling intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction protein localization establishment of protein localization nitrogen compound transport carbohydrate homeostasis cellular macromolecule localization establishment of localization in cell regulation of hormone levels establishment of protein localization to extracellular region intracellular glucose homeostasis protein secretion cellular response to oxygen-containing compound cellular response to carbohydrate stimulus response to glucose response to chemical glucose homeostasis insulin secretion involved in cellular response to glucose stimulus hormone secretion protein localization to extracellular region peptide secretion secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus cellular response to monosaccharide stimulus secretion cell-cell signaling export from cell response to oxygen-containing compound cellular response to glucose stimulus peptide transport response to hexose cellular response to chemical stimulus protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion cell population proliferation cell activation lymphocyte activation leukocyte proliferation leukocyte activation mononuclear cell proliferation immune system process T cell activation lymphocyte proliferation T cell proliferation negative regulation of protein transport negative regulation of secretion negative regulation of hormone secretion negative regulation of secretion by cell regulation of peptide hormone secretion negative regulation of peptide hormone secretion negative regulation of establishment of protein localization regulation of protein secretion regulation of secretion negative regulation of protein secretion regulation of hormone secretion regulation of protein localization regulation of peptide secretion negative regulation of signaling negative regulation of cell communication negative regulation of peptide secretion regulation of secretion by cell negative regulation of protein localization regulation of signaling negative regulation of response to stimulus regulation of peptide transport negative regulation of insulin secretion involved in cellular response to glucose stimulus regulation of establishment of protein localization regulation of protein transport negative regulation of insulin secretion regulation of cellular localization regulation of insulin secretion regulation of insulin secretion involved in cellular response to glucose stimulus regulation of cell communication regulation of heart contraction regulation of system process cardiac muscle contraction circulatory system process regulation of cardiac muscle contraction regulation of blood circulation regulation of striated muscle contraction regulation of muscle contraction heart process regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion striated muscle contraction regulation of multicellular organismal process blood circulation regulation of cardiac muscle contraction by calcium ion signaling regulation of muscle system process heart contraction negative regulation of intracellular signal transduction regulation of signal transduction regulation of intracellular signal transduction regulation of calcium-mediated signaling negative regulation of calcium-mediated signaling negative regulation of signal transduction 'de novo' protein folding response to nutrient levels response to nutrient response to vitamin E response to vitamin negative regulation of heart rate negative regulation of blood circulation negative regulation of heart contraction negative regulation of multicellular organismal process regulation of heart rate response to hydrogen peroxide response to oxidative stress response to reactive oxygen species nervous system process action potential propagation action potential transmission of nerve impulse neuronal action potential propagation regulation of membrane potential	cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril cellular anatomical structure membrane intracellular anatomical structure intracellular membraneless organelle Z disc sarcomere intracellular organelle I band organelle membraneless organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system sarcoplasm endoplasmic reticulum subcompartment bounding membrane of organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum sarcoplasmic reticulum sarcoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane protein-containing complex transmembrane transporter complex membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth F]	IPR046357	Peptidyl-prolyl cis-trans isomerase domain superfamily	Homologous Superfamily
B [auth F]	IPR050689	FKBP-type Peptidyl-prolyl cis-trans Isomerase	Family
B [auth F]	IPR001179	FKBP-type peptidyl-prolyl cis-trans isomerase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth F]	Pharos: P68106	tuberous sclerosis atopic eczema endogenous depression lung lymphangioleiomyomatosis Lymphangiomatosis renal cell carcinoma disappearing bone disease mucocutaneous lymph node syndrome dry eye syndrome lymphangioma rheumatoid arthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.