9KJU | pdb_00009kju

Local refinement of the y+LAT1-4F2hc bound with Arg

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Amino acid transporter heavy chain SLC3A2	protein binding binding virus receptor activity exogenous protein binding RNA binding double-stranded RNA binding nucleic acid binding protein heterodimerization activity protein dimerization activity alanine transmembrane transporter activity L-amino acid transmembrane transporter activity organic cation transmembrane transporter activity carboxylic acid transmembrane transporter activity amino acid transmembrane transporter activity protein binding binding virus receptor activity exogenous protein binding RNA binding double-stranded RNA binding nucleic acid binding protein heterodimerization activity protein dimerization activity alanine transmembrane transporter activity L-amino acid transmembrane transporter activity organic cation transmembrane transporter activity carboxylic acid transmembrane transporter activity amino acid transmembrane transporter activity L-alanine transmembrane transporter activity neutral L-amino acid transmembrane transporter activity transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity aromatic amino acid transmembrane transporter activity identical protein binding protein homodimerization activity cell adhesion molecule binding cadherin binding L-leucine transmembrane transporter activity branched-chain amino acid transmembrane transporter activity	amino acid transport organic acid transport localization nitrogen compound transport organic anion transport carboxylic acid transport transport neutral amino acid transport proline transport establishment of localization branched-chain amino acid transport isoleucine transport aromatic amino acid transport tyrosine transport amino acid transport organic acid transport localization nitrogen compound transport organic anion transport carboxylic acid transport transport neutral amino acid transport proline transport establishment of localization branched-chain amino acid transport isoleucine transport aromatic amino acid transport tyrosine transport L-amino acid transport organic cation transport carbohydrate metabolic process primary metabolic process metabolic process cellular process phenylalanine transport biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction thyroid hormone transport regulation of hormone levels biological regulation hormone transport regulation of biological quality response to stimulus response to chemical response to dsRNA response to nitrogen compound response to exogenous dsRNA import into cell carboxylic acid transmembrane transport amino acid transmembrane transport organic acid transmembrane transport L-alanine transmembrane transport import across plasma membrane L-alanine import across plasma membrane alanine transport transmembrane transport L-alanine transport L-alpha-amino acid transmembrane transport amino acid import across plasma membrane methionine transport sulfur amino acid transport sulfur compound transport L-leucine transport L-leucine import across plasma membrane monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport valine transport L-histidine transport basic amino acid transport histidine transport tryptophan transport	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle cell periphery cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane basal part of cell basal plasma membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell surface anchoring junction cell junction basolateral plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen vacuolar membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome somatodendritic compartment cell body cell pole apical pole of neuron neuronal cell body synapse amino acid transport complex protein-containing complex plasma membrane protein complex membrane protein complex
B	Y+L amino acid transporter 1	L-arginine transmembrane transporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity organic cation transmembrane transporter activity transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity basic amino acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity	organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization organic cation transport basic amino acid transmembrane transport L-arginine transmembrane transport organic acid transport transmembrane transport amino acid transport organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization organic cation transport basic amino acid transmembrane transport L-arginine transmembrane transport organic acid transport transmembrane transport amino acid transport localization basic amino acid transport L-alpha-amino acid transmembrane transport cellular process regulation of biological process regulation of cellular process oxoacid metabolic process biological regulation carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process regulation of primary metabolic process arginine metabolic process regulation of small molecule metabolic process regulation of arginine metabolic process regulation of amino acid metabolic process metabolic process small molecule metabolic process regulation of metabolic process neutral amino acid transport L-leucine transport branched-chain amino acid transport	cell periphery cellular anatomical structure plasma membrane membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A	IPR042280	Amino acid transporter heavy chain SLC3A2	Family
A	IPR031984	Solute carrier family 3 member 2, N-terminal domain	Domain
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR006047	Glycosyl hydrolase, family 13, catalytic domain	Domain
B	IPR002293	Amino acid/polyamine transporter I	Family
B	IPR050598	Cellular Amino Acid Transporter	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08195	breast cancer Lung Neoplasms polycystic ovary syndrome diabetes mellitus malignant ependymoma tuberculosis lung benign neoplasm
B	Pharos: Q9UM01	lysinuric protein intolerance non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm prostate carcinoma tuberculosis Amino Acid Metabolism, Inborn Errors cutaneous lupus erythematosus glioblastoma inherited amino acid metabolic disorder lung adenocarcinoma MALT lymphoma osteosarcoma pilocytic astrocytoma Sjogren syndrome ulcerative colitis lysinuric protein intolerance non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm prostate carcinoma tuberculosis Amino Acid Metabolism, Inborn Errors cutaneous lupus erythematosus glioblastoma inherited amino acid metabolic disorder lung adenocarcinoma MALT lymphoma osteosarcoma pilocytic astrocytoma Sjogren syndrome ulcerative colitis cystic fibrosis head and neck cancer intellectual disability lung cancer malignant glioma nephrosclerosis ovarian cancer plantar fibromatosis subependymal giant cell astrocytoma chronic obstructive pulmonary disease gastric carcinoma interstitial cystitis lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.