Annotations: 9NH8

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E, K [auth V]	Histone H3.2	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	-	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus membrane-enclosed lumen protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B, F	Histone H4	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	protein-containing complex organization protein-DNA complex assembly cellular component organization protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular process cellular component organization or biogenesis nucleosome assembly nucleosome organization	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
C, G	Histone H2A	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	regulation of cellular process negative regulation of biological process cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of cellular process negative regulation of biological process cellular component organization chromatin organization negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
D, H	Histone H2B 1.1	DNA binding binding nucleic acid binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	-	protein-containing complex intracellular anatomical structure protein-DNA complex nucleosome intracellular membraneless organelle chromatin chromosome intracellular organelle cellular anatomical structure organelle membraneless organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
I	DNA (158-MER)	-	-	-
J	DNA (158-MER)	-	-	-
L [auth W]	Chromodomain-helicase-DNA-binding protein 1	protein binding binding histone binding chromatin binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity protein binding binding histone binding chromatin binding nucleic acid conformation isomerase activity forked DNA-dependent helicase activity isomerase activity DNA helicase activity catalytic activity, acting on a nucleic acid helicase activity ATP-dependent activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity macromolecular conformation isomerase activity ATP-dependent chromatin remodeler activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding single-stranded DNA helicase activity 3'-5' DNA helicase activity single-stranded 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides methylated histone binding modification-dependent protein binding methylation-dependent protein binding double-stranded DNA helicase activity	viral gene expression biological process involved in interspecies interaction between organisms viral process modulation of process of another organism viral transcription positive regulation by host of viral transcription host-mediated perturbation of symbiont process cellular component organization protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling cellular process cellular component organization or biogenesis viral gene expression biological process involved in interspecies interaction between organisms viral process modulation of process of another organism viral transcription positive regulation by host of viral transcription host-mediated perturbation of symbiont process cellular component organization protein-DNA complex organization protein-containing complex organization chromatin organization chromatin remodeling cellular process cellular component organization or biogenesis nucleosome organization	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome nuclear chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E, K [auth V]	IPR009072	Histone-fold	Homologous Superfamily
A, E, K [auth V]	IPR007125	Histone H2A/H2B/H3	Domain
A, E, K [auth V]	IPR000164	Histone H3/CENP-A	Family
B, F	IPR009072	Histone-fold	Homologous Superfamily
B, F	IPR001951	Histone H4	Family
B, F	IPR035425	CENP-T/Histone H4, histone fold	Domain
B, F	IPR019809	Histone H4, conserved site	Conserved Site
B, F	IPR004823	TATA box binding protein associated factor (TAF), histone-like fold domain	Domain
C, G	IPR009072	Histone-fold	Homologous Superfamily
C, G	IPR007125	Histone H2A/H2B/H3	Domain
C, G	IPR002119	Histone H2A	Family
C, G	IPR032454	Histone H2A, C-terminal domain	Domain
C, G	IPR032458	Histone H2A conserved site	Conserved Site
D, H	IPR009072	Histone-fold	Homologous Superfamily
D, H	IPR007125	Histone H2A/H2B/H3	Domain
D, H	IPR055333	Histone H2B, conserved site	Conserved Site
D, H	IPR000558	Histone H2B	Family
L [auth W]	IPR000330	SNF2, N-terminal	Domain
L [auth W]	IPR023780	Chromo domain	Domain
L [auth W]	IPR016197	Chromo-like domain superfamily	Homologous Superfamily
L [auth W]	IPR023779	Chromo domain, conserved site	Conserved Site
L [auth W]	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
L [auth W]	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
L [auth W]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
L [auth W]	IPR000953	Chromo/chromo shadow domain	Domain
L [auth W]	IPR001650	Helicase, C-terminal domain-like	Domain
L [auth W]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
L [auth W]	IPR025260	Chromodomain-helicase-DNA-binding protein 1-like, C-terminal domain	Domain
L [auth W]	IPR056302	ATP-dependent helicase CHD1-2/hrp3, HTH domain	Domain
L [auth W]	IPR040793	CDH1/2, SANT-Helical linker 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
L [auth W]	Pharos: O14646	prostate cancer Pilarowski-Bjornsson syndrome colorectal cancer adrenal cortex carcinoma Crohn disease interstitial lung disease malignant glioma ovarian cancer colorectal adenoma diabetes mellitus large cell medulloblastoma malignant mesothelioma Prostatic Neoplasms glioblastoma lung cancer prostate cancer Pilarowski-Bjornsson syndrome colorectal cancer adrenal cortex carcinoma Crohn disease interstitial lung disease malignant glioma ovarian cancer colorectal adenoma diabetes mellitus large cell medulloblastoma malignant mesothelioma Prostatic Neoplasms glioblastoma lung cancer medulloblastoma primitive neuroectodermal tumor ulcerative colitis