Annotations: 9E1T

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13896	Glycosyl-transferase for dystroglycan (Glyco_transf_49)	Glycosyl-transferase for dystroglycan	This glycosyl-transferase brings about the glycosylation of the alpha-dystroglycan subunit. Dystroglycan is an integral member of the skeletal muscular dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix [1 ...	This glycosyl-transferase brings about the glycosylation of the alpha-dystroglycan subunit. Dystroglycan is an integral member of the skeletal muscular dystrophin glycoprotein complex, which links dystrophin to proteins in the extracellular matrix [1,2].	Domain
A, B	PF01501	Glycosyl transferase family 8 (Glyco_transf_8)	Glycosyl transferase family 8	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Xylosyl- and glucuronyltransferase LARGE1	glycosyltransferase activity transferase activity catalytic activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding UDP-glycosyltransferase activity acetylglucosaminyltransferase activity hexosyltransferase activity xylosyltransferase activity glycosyltransferase activity transferase activity catalytic activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding UDP-glycosyltransferase activity acetylglucosaminyltransferase activity hexosyltransferase activity xylosyltransferase activity pentosyltransferase activity UDP-xylosyltransferase activity glucuronosyltransferase activity	multicellular organismal process system process muscle contraction muscle system process striated muscle contraction transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport multicellular organismal process system process muscle contraction muscle system process striated muscle contraction transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport membrane organization cellular component organization plasma membrane organization cellular component organization or biogenesis endomembrane system organization developmental process multicellular organism development skeletal system development anatomical structure development animal organ development bone development system development response to light stimulus response to stimulus response to radiation response to abiotic stimulus protein localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane behavior learning or memory nervous system process cognition memory establishment of protein localization establishment of protein localization to membrane protein targeting protein targeting to membrane locomotory behavior walking behavior trans-synaptic signaling regulation of biological process signaling biological regulation cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process macromolecule biosynthetic process biosynthetic process metabolic process protein metabolic process macromolecule metabolic process organelle organization cytoskeleton organization macromolecule modification post-translational protein modification protein modification process skeletal muscle cell differentiation cellular developmental process skeletal muscle tissue development tissue development muscle cell differentiation myotube differentiation striated muscle tissue development muscle structure development skeletal muscle organ development cell differentiation skeletal muscle fiber differentiation muscle tissue development muscle organ development striated muscle cell differentiation localization of cell sensory perception sensory perception of sound sensory perception of mechanical stimulus neuromuscular process neuromuscular process controlling posture nerve development nervous system development vasculature development blood vessel development circulatory system development membrane lipid metabolic process sphingolipid biosynthetic process glycolipid metabolic process glycosphingolipid metabolic process liposaccharide metabolic process lipid biosynthetic process glycolipid biosynthetic process sphingolipid metabolic process glycosphingolipid biosynthetic process membrane lipid biosynthetic process lipid metabolic process multicellular organism growth developmental growth growth cellular response to nitrogen compound cellular response to stimulus cellular response to acetylcholine regulation of cellular process response to oxygen-containing compound response to nitrogen compound acetylcholine receptor signaling pathway postsynaptic signal transduction cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical response to acetylcholine signal transduction protein glycosylation glycosylation macromolecule glycosylation protein O-linked glycosylation defense response response to stress reactive gliosis inflammatory response neuroinflammatory response cellular homeostasis homeostatic process muscle cell cellular homeostasis cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly sensory organ development retina vasculature development in camera-type eye eye development retina development in camera-type eye visual system development camera-type eye development sensory system development myotube cell development skeletal muscle fiber development cell development striated muscle cell development muscle cell development connective tissue development fluid transport water transport head development principal sensory nucleus of trigeminal nerve development trigeminal sensory nucleus development brain development central nervous system development neural nucleus development cell junction organization neuromuscular junction development cell junction assembly synaptic assembly at neuromuscular junction synapse organization synapse assembly amino sugar metabolic process N-acetylglucosamine metabolic process glucosamine-containing compound metabolic process extracellular matrix organization basement membrane organization extracellular structure organization external encapsulating structure organization nitrogen compound transport intracellular transport protein transport establishment of localization in cell intracellular protein transport astrocyte differentiation neurogenesis gliogenesis glial cell differentiation response to mechanical stimulus response to external stimulus determination of adult lifespan gene expression myeloid leukocyte differentiation hemopoiesis macrophage differentiation mononuclear cell differentiation myeloid cell differentiation leukocyte differentiation cardiac muscle cell development cardiac cell development heart development cardiac muscle tissue development cardiac muscle cell differentiation cardiocyte differentiation tissue regeneration skeletal muscle tissue regeneration regeneration forebrain development dentate gyrus development pallium development telencephalon development hippocampus development limbic system development behavioral defense response fear response behavioral fear response multicellular organismal response to stress myelination axon ensheathment ensheathment of neurons neuron migration generation of neurons cell migration cell motility protein mannosylation protein O-linked mannosylation mannosylation retina layer formation camera-type eye morphogenesis neural retina development retina morphogenesis in camera-type eye eye morphogenesis anatomical structure morphogenesis sensory organ morphogenesis anatomical structure formation involved in morphogenesis animal organ morphogenesis limb development appendage development post-embryonic appendage morphogenesis hindlimb morphogenesis post-embryonic hindlimb morphogenesis post-embryonic limb morphogenesis appendage morphogenesis post-embryonic animal morphogenesis post-embryonic development limb morphogenesis positive regulation of cell communication modulation of chemical synaptic transmission positive regulation of biological process long-term synaptic potentiation regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity regulation of signaling positive regulation of synaptic transmission regulation of trans-synaptic signaling regulation of cell communication positive regulation of signaling	cellular anatomical structure neuromuscular junction synapse cell junction membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane cellular anatomical structure neuromuscular junction synapse cell junction membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane cell periphery plasma membrane protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR051292	Alpha-1,3-xylosyltransferase/Beta-1,3-glucuronyltransferase	Family
A, B	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A, B	IPR002495	Glycosyl transferase, family 8	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O95461	muscular dystrophy-dystroglycanopathy type B6 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A6 muscular dystrophy-dystroglycanopathy, type A amphetamine abuse congenital muscular dystrophy liver cancer Weight Gain liver neoplasm malignant colon neoplasm malignant mesothelioma muscle-eye-brain disease psoriasis cataract congenital disorder of glycosylation hydrolethalus syndrome muscular dystrophy-dystroglycanopathy type B6 muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A6 muscular dystrophy-dystroglycanopathy, type A amphetamine abuse congenital muscular dystrophy liver cancer Weight Gain liver neoplasm malignant colon neoplasm malignant mesothelioma muscle-eye-brain disease psoriasis cataract congenital disorder of glycosylation hydrolethalus syndrome lissencephaly spectrum disorders lung cancer malignant ependymoma medulloblastoma muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A, 4 osteosarcoma arthrogryposis glioblastoma intellectual disability malignant glioma muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A1 primitive neuroectodermal tumor atypical teratoid rhabdoid tumor cerebrovascular disorder cutaneous lupus erythematosus hydrocephalus large cell medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.