Download MendeleyProdystroglycan defines matriglycan lengths processively polymerized by LARGE1
Joesph, S., Spellmon, N., Schnicker, N.J., Xu, Z., Yang, T., Hopkins, J., Chakravarthy, S., Davulcu, O., Anderson, M.E., Venzke, D., Campbell, K.P.To be published.
9E1T
CryoEM structure of LARGE1 bound to UDP
- PDB DOI: https://doi.org/10.2210/pdb9E1T/pdb
- EM Map EMD-47420: EMDB EMDataResource
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2024-10-21 Released: 2025-02-12
- Funding Organization(s): Howard Hughes Medical Institute (HHMI), National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.00 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Xylosyl- and glucuronyltransferase LARGE1 | 770 | Homo sapiens | Mutation(s): 0 Gene Names: LARGE1, KIAA0609, LARGE EC: 2.4 (PDB Primary Data), 2.4.2 (PDB Primary Data), 2.4.1 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O95461 (Homo sapiens) Explore O95461 Go to UniProtKB: O95461 | |||||
PHAROS: O95461 GTEx: ENSG00000133424 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O95461 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| UDP (Subject of Investigation/LOI) Query on UDP | D [auth A], F [auth B] | URIDINE-5'-DIPHOSPHATE C9 H14 N2 O12 P2 XCCTYIAWTASOJW-XVFCMESISA-N |  | ||
| MN (Subject of Investigation/LOI) Query on MN | C [auth A], E [auth B] | MANGANESE (II) ION Mn WAEMQWOKJMHJLA-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.00 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Entry History & Funding Information
Deposition Data
- Released Date: 2025-02-12 Deposition Author(s): Joesph, S., Spellmon, N., Campbell, K.P.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Howard Hughes Medical Institute (HHMI) | United States | -- |
| National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) | United States | U54 NS053672 |
| National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) | United States | U24 GM129547 |
Revision History (Full details and data files)
- Version 1.0: 2025-02-12
Type: Initial release
