Crystallographic fragment screening of Human heat shock protein 90
PDB deposit group Id: G_1002298
Grouped By: Matching PDB Deposit Group ID
Group Content:
PDB deposit group description: Heat shock protein 90 (HSP90) is one of the most active molecular chaperones in cells. It plays a vital role in the cell maturation process and serves as a molecular chaperone involved in many oncogenic proteins folding, assembly and stabilization. Many HSP90 client proteins are kinases or transcription factors involved in signal transduction pathways and are key regulatory factors in tumor growth and maintenance. Therefore, HSP90 inhibitors can be used as drugs for cancer treatment.
Experimental Features
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Small Molecules
