Cyclic GMP-AMP synthase-like receptor 1

UniProtKB accession:  A0A2B4RP11

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UniProtKB description:  Nucleotidyltransferase that catalyzes the formation of cyclic UMP-AMP (3',3'-cUAMP) from ATP and UTP and plays a key role in innate immunity (PubMed:37379839). Acts as a key sensor of double-stranded RNA (dsRNA), the presence of dsRNA in the cytoplasm being a danger signal that triggers the immune responses (PubMed:37379839). Directly binds dsRNA, activating the nucleotidyltransferase activity, leading to synthesis of 3',3'-cUAMP, a second messenger that binds to and activates Sting, thereby triggering the immune response via activation of the NF-kappa-B transcription factor (PubMed:37379839).