Inosine/xanthosine triphosphatase

UniProtKB accession:  P39411

Grouped By:  Matching UniProtKB accession

UniProtKB description:  Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. ITP and XTP are the best substrates, followed by GDP and dITP. Is not active on dATP and dGTP, and exhibits no phosphatase activity toward pyrimidines (CTP, TTP, UTP, dCTP, and dTTP) (PubMed:16216582). Also seems to be implicated in the resistance against the thiamine metabolism inhibitors bacimethrin and CF3-HMP (PubMed:15292217).