Download MendeleyAllosetric regulation of M2 pyruvate kinase.
Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.To be published.
3SRH
Human M2 pyruvate kinase
- PDB DOI: https://doi.org/10.2210/pdb3SRH/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2011-07-07 Released: 2012-08-08
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.60 ?
- R-Value Free: 0.270
- R-Value Work: 0.217
- R-Value Observed: 0.219
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Pyruvate kinase isozymes M1/M2 | 551 | Homo sapiens | Mutation(s): 0 Gene Names: OIP3, PK2, PK3, PKM, PKM2 EC: 2.7.1.40 (PDB Primary Data), 2.7.11.1 (UniProt), 2.7.10.2 (UniProt) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P14618 (Homo sapiens) Explore P14618 Go to UniProtKB: P14618 | |||||
PHAROS: P14618 GTEx: ENSG00000067225 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P14618 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PO4 Query on PO4 | E [auth A], F [auth B], G [auth D] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.60 ?
- R-Value Free: 0.270
- R-Value Work: 0.217
- R-Value Observed: 0.219
- Space Group: P 1 21 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 81.2 | ¦Á = 90 |
| b = 154.31 | ¦Â = 105.59 |
| c = 98.59 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| DNA | data collection |
| PHASER | phasing |
| REFMAC | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
Entry History
Deposition Data
- Released Date: 2012-08-08 Deposition Author(s): Morgan, H.P., O'Reilly, F., Palmer, R., McNae, I.W., Nowicki, M.W., Wear, M.A., Fothergill-Gilmore, L.A., Walkinshaw, M.D.
Revision History (Full details and data files)
- Version 1.0: 2012-08-08
Type: Initial release - Version 1.1: 2024-02-28
Changes: Data collection, Database references, Derived calculations
