Download MendeleyCrystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
Qi, X., Zhou, A.To be published.
4X30
Crystal structure of human Thyroxine-binding globulin complexed with thyroine at 1.55 Angstrom resolution
- PDB DOI: https://doi.org/10.2210/pdb4X30/pdb
- Classification: TRANSPORT PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2014-11-27 Released: 2015-12-02
- Funding Organization(s): National Natural Science Foundation of China, nsfc
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.55 ?
- R-Value Free: 0.205
- R-Value Work: 0.183
- R-Value Observed: 0.184
Starting Model: experimental
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This is version 2.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Thyroxine-binding globulin | 395 | Homo sapiens | Mutation(s): 0 Gene Names: SERPINA7, TBG |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P05543 (Homo sapiens) Explore P05543 Go to UniProtKB: P05543 | |||||
PHAROS: P05543 GTEx: ENSG00000123561 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P05543 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 5 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| T44 Query on T44 | B [auth A] | 3,5,3',5'-TETRAIODO-L-THYRONINE C15 H11 I4 N O4 XUIIKFGFIJCVMT-LBPRGKRZSA-N |  | ||
| GOL Query on GOL | C [auth A], D [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| EDO Query on EDO | F [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
| NA Query on NA | G [auth A] | SODIUM ION Na FKNQFGJONOIPTF-UHFFFAOYSA-N |  | ||
| F Query on F | E [auth A] | FLUORIDE ION F KRHYYFGTRYWZRS-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.55 ?
- R-Value Free: 0.205
- R-Value Work: 0.183
- R-Value Observed: 0.184
- Space Group: P 43 21 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 65.46 | ¦Á = 90 |
| b = 65.46 | ¦Â = 90 |
| c = 202.71 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| Coot | model building |
| MOSFLM | data processing |
| PHASER | phasing |
| SCALA | data reduction |
| SCALEPACK | data scaling |
Entry History & Funding Information
Deposition Data
- Released Date: 2015-12-02 Deposition Author(s): Qi, X.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China | China | 31170724 |
| nsfc | China | 31370727 |
Revision History (Full details and data files)
- Version 1.0: 2015-12-02
Type: Initial release - Version 1.1: 2017-10-18
Changes: Author supporting evidence, Database references, Derived calculations - Version 1.2: 2023-11-08
Changes: Data collection, Database references, Refinement description - Version 2.0: 2023-11-15
Changes: Atomic model, Data collection
