Download MendeleyHuman STK10 bound to GW683134
Sorrell, F.J., Elkins, J.M.To be published.
6I2Y
Human STK10 bound to Foretinib
- PDB DOI: https://doi.org/10.2210/pdb6I2Y/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2018-11-02 Released: 2018-12-12
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.56 ?
- R-Value Free: 0.283
- R-Value Work: 0.263
- R-Value Observed: 0.264
This is version 1.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Serine/threonine-protein kinase 10 | 302 | Homo sapiens | Mutation(s): 0 Gene Names: STK10, LOK EC: 2.7.11.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O94804 (Homo sapiens) Explore O94804 Go to UniProtKB: O94804 | |||||
PHAROS: O94804 GTEx: ENSG00000072786 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O94804 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 88Z (Subject of Investigation/LOI) Query on 88Z | C [auth A], D [auth B] | N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide C34 H34 F2 N4 O6 CXQHYVUVSFXTMY-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.56 ?
- R-Value Free: 0.283
- R-Value Work: 0.263
- R-Value Observed: 0.264
- Space Group: P 21 21 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 50.93 | ¦Á = 90 |
| b = 95.33 | ¦Â = 90 |
| c = 132.86 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| XDS | data reduction |
| Aimless | data scaling |
| PHENIX | refinement |
| PDB_EXTRACT | data extraction |
| REFMAC | phasing |
Entry History
Deposition Data
- Released Date: 2018-12-12 Deposition Author(s): Sorrell, F.J., Berger, B.-T., Oerum, S., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Elkins, J.M.
Revision History (Full details and data files)
- Version 1.0: 2018-12-12
Type: Initial release - Version 1.1: 2024-11-20
Changes: Data collection, Database references, Refinement description, Structure summary
