Download MendeleyA CENTRAL PEPTIDE RESIDUE CAN CONTROL MHC POLYMORPHISM-DEPENDENT ANTIGEN PRESENTATION
Loll, B., Rueckert, C., Ziegler, B.-U., Ziegler, A.To be published.
6Y2A
Crystal structure of HLA-B2705 complexed with the nona-peptide mQ
- PDB DOI: https://doi.org/10.2210/pdb6Y2A/pdb
- Classification: IMMUNE SYSTEM
- Organism(s): Homo sapiens, synthetic construct
- Expression System: Escherichia coli, synthetic construct
- Mutation(s): No
- Deposited: 2020-02-15 Released: 2020-12-23
- Funding Organization(s): German Research Foundation (DFG)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.25 ?
- R-Value Free: 0.155
- R-Value Work: 0.129
- R-Value Observed: 0.131
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| MHC class I antigen | 276 | Homo sapiens | Mutation(s): 0 Gene Names: HLA-B |  | |
UniProt | |||||
Find proteins for A0A6B7HFJ9 (Homo sapiens) Explore A0A6B7HFJ9 Go to UniProtKB: A0A6B7HFJ9 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A6B7HFJ9 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Beta-2-microglobulin | 100 | Homo sapiens | Mutation(s): 0 Gene Names: B2M, CDABP0092, HDCMA22P |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61769 (Homo sapiens) Explore P61769 Go to UniProtKB: P61769 | |||||
PHAROS: P61769 GTEx: ENSG00000166710 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P61769 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| mQ | 9 | synthetic construct | Mutation(s): 0 |  | |
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GOL Query on GOL | D [auth A], E [auth A], F [auth A], G [auth A], H [auth B] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.25 ?
- R-Value Free: 0.155
- R-Value Work: 0.129
- R-Value Observed: 0.131
- Space Group: P 21 21 21
- Diffraction Data: https://doi.org/10.18430/m36y2a
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 50.89 | ¦Á = 90 |
| b = 82.32 | ¦Â = 90 |
| c = 109.61 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| XSCALE | data scaling |
| PHASER | phasing |
| DNA | data collection |
Entry History & Funding Information
Deposition Data
- Released Date: 2020-12-23 Deposition Author(s): Loll, B., Rueckert, C., Ziegler, B.-U., Ziegler, A.
| Funding Organization | Location | Grant Number |
|---|---|---|
| German Research Foundation (DFG) | Germany | SfB 449 |
Revision History (Full details and data files)
- Version 1.0: 2020-12-23
Type: Initial release - Version 1.1: 2024-01-24
Changes: Data collection, Database references, Refinement description - Version 1.2: 2024-10-16
Changes: Structure summary
