Structure of human DNA polymerase beta complexed with dzA in the template base paired with incoming non-hydrolyzable TTP
Koag, M.-C., Lee, S.To be published.
Experimental Data Snapshot
Starting Model: experimental
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Entity ID: 4 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
DNA polymerase beta | D [auth A] | 326 | Homo sapiens | Mutation(s): 0  Gene Names: POLB EC: 2.7.7.7 (PDB Primary Data), 4.2.99 (PDB Primary Data), 4.2.99.18 (UniProt) | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P06746 (Homo sapiens) Explore P06746  Go to UniProtKB:  P06746 | |||||
PHAROS:  P06746 GTEx:  ENSG00000070501  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P06746 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 1 | |||||
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Molecule | Chains | Length | Organism | Image | |
DNA (5'-D(*CP*CP*GP*AP*CP*(4DU)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | A [auth T] | 16 | Homo sapiens | ||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Length | Organism | Image | |
DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3') | B [auth P] | 10 | Homo sapiens | ||
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Entity ID: 3 | |||||
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Molecule | Chains | Length | Organism | Image | |
DNA (5'-D(P*GP*TP*CP*GP*G)-3') | C [auth D] | 5 | Homo sapiens | ||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
1FZ (Subject of Investigation/LOI) Query on 1FZ | I [auth A] | 5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]thymidine C10 H18 N3 O13 P3 YRKUYVYMPXAOAT-XLPZGREQSA-N | |||
MG (Subject of Investigation/LOI) Query on MG | E [auth A], F [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N | |||
NA (Subject of Investigation/LOI) Query on NA | G [auth A], H [auth A] | SODIUM ION Na FKNQFGJONOIPTF-UHFFFAOYSA-N |
Length ( ? ) | Angle ( ? ) |
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a = 50.319 | ¦Á = 90 |
b = 79.839 | ¦Â = 107.29 |
c = 55.324 | ¦Ă = 90 |
Software Name | Purpose |
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HKL-2000 | data scaling |
PHENIX | refinement |
PDB_EXTRACT | data extraction |
HKL-2000 | data reduction |
MOLREP | phasing |
Funding Organization | Location | Grant Number |
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National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS) | United States | ES-26676 |