Download MendeleyMolecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Ha, B.H., Yigit, S., Natarajan, N., Morse, E.M., Calderwood, D.A., Boggon, T.J.(2022) Commun Biol 5: 1257
7S47
Integrin beta5(743-774)-linker-PAK4cat(D440N/S474E)
- PDB DOI: https://doi.org/10.2210/pdb7S47/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2021-09-08 Released: 2022-11-09
- Funding Organization(s): National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 ?
- R-Value Free: 0.237
- R-Value Work: 0.194
- R-Value Observed: 0.196
Starting Model: experimental
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This is version 1.2 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Integrin beta-5, Isoform 2 of Serine/threonine-protein kinase PAK 4 chimera | 383 | Homo sapiens | Mutation(s): 2 Gene Names: ITGB5, PAK4, KIAA1142 EC: 2.7.11.1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P18084 (Homo sapiens) Explore P18084 Go to UniProtKB: P18084 | |||||
PHAROS: P18084 GTEx: ENSG00000082781 | |||||
Find proteins for O96013 (Homo sapiens) Explore O96013 Go to UniProtKB: O96013 | |||||
PHAROS: O96013 GTEx: ENSG00000130669 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Groups | O96013P18084 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Integrin beta-5 | 32 | Homo sapiens | Mutation(s): 0 Gene Names: ITGB5 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P18084 (Homo sapiens) Explore P18084 Go to UniProtKB: P18084 | |||||
PHAROS: P18084 GTEx: ENSG00000082781 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P18084 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ANP (Subject of Investigation/LOI) Query on ANP | C [auth A] | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER C10 H17 N6 O12 P3 PVKSNHVPLWYQGJ-KQYNXXCUSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 ?
- R-Value Free: 0.237
- R-Value Work: 0.194
- R-Value Observed: 0.196
- Space Group: P 41 21 2
- Diffraction Data: https://doi.org/10.15785/SBGRID/854
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 62.321 | ¦Á = 90 |
| b = 62.321 | ¦Â = 90 |
| c = 178.609 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| HKL-2000 | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| HKL-2000 | data reduction |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2022-11-09 Deposition Author(s): Ha, B.H., Boggon, T.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | R01GM138411 |
Revision History (Full details and data files)
- Version 1.0: 2022-11-09
Type: Initial release - Version 1.1: 2022-11-23
Changes: Database references - Version 1.2: 2023-10-25
Changes: Data collection, Refinement description
