Download MendeleyEvolutionary tuning of a key helix drove androgen selectivity
Little, M.M., Ortlund, E.A.To be published.
8GL7
AncAR1 - progesterone - Tif2
- PDB DOI: https://doi.org/10.2210/pdb8GL7/pdb
- Classification: SIGNALING PROTEIN
- Organism(s): Escherichia coli, Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2023-03-21 Released: 2024-06-26
- Funding Organization(s): National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 ?
- R-Value Free: 0.253
- R-Value Work: 0.197
- R-Value Observed: 0.200
Starting Model: experimental
View more details
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Ancestral androgen receptor | 248 | Escherichia coli | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Nuclear receptor coactivator 2 | B [auth D] | 9 | Homo sapiens | Mutation(s): 0 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q15596 (Homo sapiens) Explore Q15596 Go to UniProtKB: Q15596 | |||||
PHAROS: Q15596 GTEx: ENSG00000140396 | |||||
Entity Groups | |||||
| UniProt Group | Q15596 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| STR (Subject of Investigation/LOI) Query on STR | C [auth A] | PROGESTERONE C21 H30 O2 RJKFOVLPORLFTN-LEKSSAKUSA-N |  | ||
| GOL Query on GOL | D [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.40 ?
- R-Value Free: 0.253
- R-Value Work: 0.197
- R-Value Observed: 0.200
- Space Group: P 43 21 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 69.714 | ¦Á = 90 |
| b = 69.714 | ¦Â = 90 |
| c = 144.439 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| PDB-REDO | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-06-26 Deposition Author(s): Little, M.M., Ortlund, E.A.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | United States | R56DK115213 |
Revision History (Full details and data files)
- Version 1.0: 2024-06-26
Type: Initial release
