Download MendeleyHIF prolyl hydroxylase 2 in complex with HIF2alpha-CODD
Fiorini, G., Figg Jr, W.D., Schofield, C.J.To be published.
8Q64
Crystal structure of hydroxylated HIF2alpha-CODD peptide (523-542) bound to apo-HIF prolyl hydroxylase 2 (PHD2 181-407)
- PDB DOI: https://doi.org/10.2210/pdb8Q64/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli 'BL21-Gold(DE3)pLysS AG
- Mutation(s): No
- Deposited: 2023-08-10 Released: 2024-08-21
- Funding Organization(s): Wellcome Trust, University of Oxford, Medical Sciences Internal Fund (MSIF), Cancer Research UK, Biotechnology and Biological Sciences Research Council (BBSRC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.36 ?
- R-Value Free: 0.212
- R-Value Work: 0.190
- R-Value Observed: 0.191
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Egl nine homolog 1 | 232 | Homo sapiens | Mutation(s): 0 Gene Names: EGLN1, C1orf12, PNAS-118, PNAS-137 EC: 1.14.11.29 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9GZT9 (Homo sapiens) Explore Q9GZT9 Go to UniProtKB: Q9GZT9 | |||||
PHAROS: Q9GZT9 GTEx: ENSG00000135766 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9GZT9 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Endothelial PAS domain-containing protein 1 | 20 | Homo sapiens | Mutation(s): 0 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q99814 (Homo sapiens) Explore Q99814 Go to UniProtKB: Q99814 | |||||
PHAROS: Q99814 GTEx: ENSG00000116016 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q99814 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ACT Query on ACT | C [auth A], D [auth A], E [auth A], F [auth A] | ACETATE ION C2 H3 O2 QTBSBXVTEAMEQO-UHFFFAOYSA-M |  | ||
| Modified Residues 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| HYP Query on HYP | B | L-PEPTIDE LINKING | C5 H9 N O3 |  | PRO |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.36 ?
- R-Value Free: 0.212
- R-Value Work: 0.190
- R-Value Observed: 0.191
- Space Group: P 21 2 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 38.054 | ¦Á = 90 |
| b = 42.467 | ¦Â = 90 |
| c = 130.457 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| PHASER | phasing |
| DIALS | data reduction |
| xia2 | data scaling |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-08-21 Deposition Author(s): Fiorini, G., Figg Jr, W.D., Schofield, C.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Wellcome Trust | United Kingdom | -- |
| University of Oxford, Medical Sciences Internal Fund (MSIF) | United Kingdom | -- |
| Cancer Research UK | United Kingdom | -- |
| Biotechnology and Biological Sciences Research Council (BBSRC) | United Kingdom | -- |
Revision History (Full details and data files)
- Version 1.0: 2024-08-21
Type: Initial release
