Download MendeleyCrystal structure of Human TEAD2 in complex with Cobimetinib
He, X.J., Hu, L.Q., Wu, M.Y.To be published.
8YGQ | pdb_00008ygq
Crystal structure of Human TEAD2 in complex with Cobimetinib
- PDB DOI: https://doi.org/10.2210/pdb8YGQ/pdb
- Classification: TRANSCRIPTION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-02-26 Released: 2025-03-05
- Funding Organization(s): National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.71 ?
- R-Value Free: 0.257 (Depositor), 0.258 (DCC)
- R-Value Work: 0.191 (Depositor), 0.193 (DCC)
- R-Value Observed: 0.198 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Transcriptional enhancer factor TEF-4 | 226 | Homo sapiens | Mutation(s): 0 Gene Names: TEAD2, TEF4 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q15562 (Homo sapiens) Explore Q15562 Go to UniProtKB: Q15562 | |||||
PHAROS: Q15562 GTEx: ENSG00000074219 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q15562 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| EUI (Subject of Investigation/LOI) Query on EUI | D [auth B] | [3,4-BIS(FLUORANYL)-2-[(2-FLUORANYL-4-IODANYL-PHENYL)AMINO]PHENYL]-[3-OXIDANYL-3-[(2S)-PIPERIDIN-2-YL]AZETIDIN-1-YL]METHANONE C21 H21 F3 I N3 O2 BSMCAPRUBJMWDF-KRWDZBQOSA-N |  | ||
| PLM Query on PLM | C [auth A] | PALMITIC ACID C16 H32 O2 IPCSVZSSVZVIGE-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.71 ?
- R-Value Free: 0.257 (Depositor), 0.258 (DCC)
- R-Value Work: 0.191 (Depositor), 0.193 (DCC)
- R-Value Observed: 0.198 (Depositor)
Space Group: C 1 2 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 122.303 | ¦Á = 90 |
| b = 61.774 | ¦Â = 117.7 |
| c = 80.361 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-3000 | data reduction |
| HKL-3000 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Natural Science Foundation of China (NSFC) | China | 31970672 |
| National Natural Science Foundation of China (NSFC) | China | 32270877 |
Revision History (Full details and data files)
- Version 1.0: 2025-03-05
Type: Initial release
