8Y2M

Cryo-EM structure of the FB1-bound Lac1-Lip1 complex

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF03798	TLC domain (TRAM_LAG1_CLN8)	TLC domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Ceramide synthase LAC1	acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity sphingosine N-acyltransferase activity catalytic activity N-acyltransferase activity	ceramide metabolic process membrane lipid metabolic process sphingolipid biosynthetic process lipid biosynthetic process amide biosynthetic process sphingolipid metabolic process primary metabolic process biosynthetic process ceramide biosynthetic process metabolic process cellular process amide metabolic process membrane lipid biosynthetic process lipid metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen protein-containing complex acyl-CoA ceramide synthase complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen protein-containing complex acyl-CoA ceramide synthase complex catalytic complex endoplasmic reticulum cytoplasm endomembrane system organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane
B, D	Ceramide synthase subunit LIP1	-	ceramide metabolic process membrane lipid metabolic process sphingolipid biosynthetic process lipid biosynthetic process amide biosynthetic process sphingolipid metabolic process primary metabolic process biosynthetic process ceramide biosynthetic process metabolic process cellular process amide metabolic process membrane lipid biosynthetic process lipid metabolic process	protein-containing complex acyl-CoA ceramide synthase complex catalytic complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum protein-containing complex acyl-CoA ceramide synthase complex catalytic complex membrane-bounded organelle intracellular organelle organelle envelope cellular anatomical structure intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum cytoplasm organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR016439	Sphingosine N-acyltransferase Lag1/Lac1-like	Family
A, C	IPR006634	TRAM/LAG1/CLN8 homology domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.