8ZIA | pdb_00008zia

The L-tryptophan specific decarboxylase PsiD(50-439) in complex with tryptamine

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth I], C [auth A]	L-tryptophan decarboxylase	phosphatidylserine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity L-tryptophan decarboxylase activity aromatic-L-amino-acid decarboxylase activity	glycerophospholipid biosynthetic process phosphatidylethanolamine metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphatidylethanolamine biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process glycerophospholipid biosynthetic process phosphatidylethanolamine metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphatidylethanolamine biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process alkaloid biosynthetic process oxoacid metabolic process indole alkaloid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process secondary metabolic process mycotoxin metabolic process secondary metabolite biosynthetic process L-tryptophan metabolic process indole-containing compound biosynthetic process indolalkylamine metabolic process psilocybin biosynthetic process indole alkaloid biosynthetic process small molecule metabolic process toxin metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process mycotoxin biosynthetic process carboxylic acid metabolic process alkaloid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process amine metabolic process toxin biosynthetic process biogenic amine metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle
B [auth J], D [auth B]	L-tryptophan decarboxylase	phosphatidylserine decarboxylase activity carboxy-lyase activity lyase activity catalytic activity carbon-carbon lyase activity L-tryptophan decarboxylase activity aromatic-L-amino-acid decarboxylase activity	glycerophospholipid biosynthetic process phosphatidylethanolamine metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphatidylethanolamine biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process glycerophospholipid biosynthetic process phosphatidylethanolamine metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process phosphatidylethanolamine biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process phosphate-containing compound metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process alkaloid biosynthetic process oxoacid metabolic process indole alkaloid metabolic process indole-containing compound metabolic process amino acid metabolic process organic acid metabolic process alpha-amino acid metabolic process secondary metabolic process mycotoxin metabolic process secondary metabolite biosynthetic process L-tryptophan metabolic process indole-containing compound biosynthetic process indolalkylamine metabolic process psilocybin biosynthetic process indole alkaloid biosynthetic process small molecule metabolic process toxin metabolic process erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process aromatic amino acid metabolic process mycotoxin biosynthetic process carboxylic acid metabolic process alkaloid metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process amine metabolic process toxin biosynthetic process biogenic amine metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth I], C [auth A]	IPR003817	Phosphatidylserine decarboxylase-related	Family
A [auth I], C [auth A]	IPR022237	L-tryptophan decarboxylase PsiD-like	Domain
B [auth J], D [auth B]	IPR003817	Phosphatidylserine decarboxylase-related	Family
B [auth J], D [auth B]	IPR022237	L-tryptophan decarboxylase PsiD-like	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth J], D [auth B]	PYR	RESID: AA0127 PSI-MOD : pyruvic acid (Cys) MOD:00136 , pyruvic acid (Ser) MOD:00807 , pyruvic acid MOD:01154 , pyruvic acid (Tyr) MOD:01661

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.