5V54

Crystal structure of 5-HT1B receptor in complex with methiothepin

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091186	3000473	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091186	3000473	SCOP2B (2022-06-29)
B	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8091185	4001858	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	G protein-coupled receptor-like	8091186	3000473	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_2	e5v54A2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
A	Cytochrom_B562_1	e5v54A1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Cytochromes (From Topology)	T: Cytochromes	F: Cytochrom_B562_1	ECOD (1.6)
B	7tm_1_2	e5v54B1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
B	Cytochrom_B562_1	e5v54B2	A: alpha bundles	X: Four-helical up-and-down bundle	H: Cytochromes (From Topology)	T: Cytochromes	F: Cytochrom_B562_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GC ...	This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B	cation binding binding ion binding serotonin binding amine binding heterocyclic compound binding small molecule binding G protein-coupled amine receptor activity G protein-coupled serotonin receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity Gi/o-coupled serotonin receptor activity cation binding binding ion binding serotonin binding amine binding heterocyclic compound binding small molecule binding G protein-coupled amine receptor activity G protein-coupled serotonin receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity Gi/o-coupled serotonin receptor activity neurotransmitter receptor activity serotonin receptor activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	multicellular organismal process tissue remodeling bone remodeling cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-inhibiting serotonin receptor signaling pathway G protein-coupled serotonin receptor signaling pathway cell communication adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway multicellular organismal process tissue remodeling bone remodeling cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-inhibiting serotonin receptor signaling pathway G protein-coupled serotonin receptor signaling pathway cell communication adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction monoamine transport regulation of localization nitrogen compound transport transport negative regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport organic hydroxy compound transport localization secretion by cell negative regulation of secretion regulation of secretion by cell signal release negative regulation of cellular process monoatomic ion transport negative regulation of secretion by cell serotonin secretion negative regulation of serotonin secretion regulation of transport secretion regulation of monoatomic ion transport cell-cell signaling export from cell serotonin transport regulation of serotonin secretion establishment of localization regulation of secretion phospholipase C-activating serotonin receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission presynaptic modulation of chemical synaptic transmission chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of catecholamine secretion dopamine transport catecholamine transport dopamine secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion regulation of tube diameter system process regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size regulation of vascular associated smooth muscle cell proliferation cell population proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation positive regulation of biological process smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation positive regulation of cellular process response to corticosteroid response to lipid response to hormone response to steroid hormone response to chemical response to endogenous stimulus response to mineralocorticoid cellular response to nitrogen compound cellular response to chemical stimulus response to nitrogen compound cellular response to alkaloid response to alkaloid negative regulation of amino acid transport negative regulation of amine transport gamma-aminobutyric acid transport negative regulation of gamma-aminobutyric acid secretion regulation of amino acid transport organic anion transport gamma-aminobutyric acid secretion carboxylic acid transport regulation of gamma-aminobutyric acid secretion acid secretion organic acid transport amino acid transport negative regulation of organic acid transport regulation of organic acid transport regulation of behavior behavior regulation of multicellular organismal process drinking behavior feeding behavior response to alcohol response to oxygen-containing compound response to ethanol negative regulation of signaling synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission negative regulation of cell communication negative regulation of synaptic transmission, glutamatergic cellular response to xenobiotic stimulus response to xenobiotic stimulus negative regulation of synaptic transmission, GABAergic synaptic transmission, GABAergic regulation of synaptic transmission, GABAergic cellular localization regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport vesicle-mediated transport in synapse regulation of regulated secretory pathway establishment of localization in cell neurotransmitter secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis neurotransmitter transport regulation of vesicle-mediated transport signal release from synapse exocytosis regulation of neurotransmitter secretion regulation of exocytosis response to cocaine G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	protein-containing complex G protein-coupled serotonin receptor complex receptor complex cellular anatomical structure serotonergic synapse synapse cell junction cell periphery plasma membrane membrane presynapse presynaptic membrane plasma membrane region synaptic membrane protein-containing complex G protein-coupled serotonin receptor complex receptor complex cellular anatomical structure serotonergic synapse synapse cell junction cell periphery plasma membrane membrane presynapse presynaptic membrane plasma membrane region synaptic membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection axon axon terminus distal axon calyx of Held neuron projection terminus membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002147	5-Hydroxytryptamine 1B receptor	Family
A, B	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A, B	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A, B	IPR002231	5-hydroxytryptamine receptor family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P28222	visual epilepsy major depressive disorder schizoaffective disorder cocaine abuse migraine disorder amphetamine abuse cocaine dependence Generalized seizures hypotensive disorder osteosarcoma autism schizophreniform disorder depressive disorder large cell medulloblastoma opiate dependence visual epilepsy major depressive disorder schizoaffective disorder cocaine abuse migraine disorder amphetamine abuse cocaine dependence Generalized seizures hypotensive disorder osteosarcoma autism schizophreniform disorder depressive disorder large cell medulloblastoma opiate dependence bipolar disorder

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.