8QYQ | pdb_00008qyq

Beta-cardiac myosin S1 fragment in the pre-powerstroke state complexed to Mavacamten

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	EF-hand	8062873	3001983	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A, B	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Myosin-7	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding calmodulin binding polypeptide conformation or assembly isomerase activity isomerase activity cytoskeletal motor activity microfilament motor activity macromolecular conformation isomerase activity catalytic activity ATP-dependent activity	heart process multicellular organismal process system process circulatory system process cardiac muscle contraction heart contraction muscle contraction muscle system process blood circulation striated muscle contraction developmental process heart development multicellular organism development anatomical structure development heart process multicellular organismal process system process circulatory system process cardiac muscle contraction heart contraction muscle contraction muscle system process blood circulation striated muscle contraction developmental process heart development multicellular organism development anatomical structure development animal organ development adult heart development circulatory system development system development muscle filament sliding actin filament-based process cellular process actin-mediated cell contraction actin filament-based movement actin-myosin filament sliding	protein-containing complex intracellular anatomical structure intracellular membraneless organelle actin cytoskeleton myosin complex intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle myosin II complex sarcomere contractile muscle fiber cytoplasm protein-containing complex intracellular anatomical structure intracellular membraneless organelle actin cytoskeleton myosin complex intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle myosin II complex sarcomere contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex myosin filament
C	Myosin light chain 3	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	protein-containing complex intracellular anatomical structure intracellular membraneless organelle actin cytoskeleton myosin complex intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle myosin II complex
D	Myosin light chain 3	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	protein-containing complex intracellular anatomical structure intracellular membraneless organelle actin cytoskeleton myosin complex intracellular organelle cellular anatomical structure cytoskeleton organelle membraneless organelle myosin II complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A, B	IPR001609	Myosin head, motor domain-like	Domain
A, B	IPR002928	Myosin tail	Domain
A, B	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, B	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR050230	Calmodulin/Myosin light chain/Troponin C-like	Family
C	IPR002048	EF-hand domain	Domain
C	IPR011992	EF-hand domain pair	Homologous Superfamily
D	IPR050230	Calmodulin/Myosin light chain/Troponin C-like	Family
D	IPR002048	EF-hand domain	Domain
D	IPR011992	EF-hand domain pair	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	M3L	Parent Component: LYS RESID: AA0074 PSI-MOD : N6,N6,N6-trimethyl-L-lysine MOD:00083

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.