Annotations: 8V0D

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	UBC-like	8040137	3000570	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	UBC-like	8040137	3000570	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF00179	Ubiquitin-conjugating enzyme (UQ_con)	Ubiquitin-conjugating enzyme	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cystein ...	Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].	Domain
A [auth B], B [auth A]	PF13920	Zinc finger, C3HC4 type (RING finger) (zf-C3HC4_3)	Zinc finger, C3HC4 type (RING finger)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Ubch5B-RING3 of MIB1 fusion protein	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ubiquitin conjugating enzyme activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein conjugating enzyme activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding ubiquitin-like protein ligase activity ubiquitin protein ligase activity cation binding transition metal ion binding zinc ion binding metal ion binding	catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein polyubiquitination catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein K48-linked ubiquitination protein autoubiquitination multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons negative regulation of neuron differentiation regulation of neuron differentiation somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis localization import into cell transport endocytosis establishment of localization vesicle-mediated transport embryonic epithelial tube formation tube formation epithelial tube formation tube morphogenesis epithelial tube morphogenesis morphogenesis of embryonic epithelium neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium tissue morphogenesis neural tube formation in utero embryonic development vasculature development blood vessel development circulatory system development cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication Notch signaling pathway signal transduction regulation of localization positive regulation of cellular component organization regulation of cellular component organization regulation of transport positive regulation of biological process regulation of vesicle-mediated transport cellular component organization positive regulation of endocytosis positive regulation of transport cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis heart morphogenesis embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry animal organ morphogenesis embryonic organ development determination of left/right symmetry specification of symmetry embryonic organ morphogenesis heart development animal organ development determination of heart left/right asymmetry left/right pattern formation	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex centrosome microtubule organizing center cytoskeleton membraneless organelle intracellular membraneless organelle microtubule cytoskeleton centriolar satellite cell periphery plasma membrane membrane synapse cell junction glutamatergic synapse cytoplasmic vesicle intracellular vesicle postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR000608	Ubiquitin-conjugating enzyme E2	Domain
A [auth B], B [auth A]	IPR016135	Ubiquitin-conjugating enzyme/RWD-like	Homologous Superfamily
A [auth B], B [auth A]	IPR023313	Ubiquitin-conjugating enzyme, active site	Active Site
A [auth B], B [auth A]	IPR040847	Mind bomb, SH3 repeat domain	Domain
A [auth B], B [auth A]	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR010606	Mib-herc2	Domain
A [auth B], B [auth A]	IPR000433	Zinc finger, ZZ-type	Domain
A [auth B], B [auth A]	IPR002110	Ankyrin repeat	Repeat
A [auth B], B [auth A]	IPR037252	Mib/herc2 domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A [auth B], B [auth A]	IPR042056	E3 ubiquitin-protein ligase MIB1/2, zinc finger, ZZ-type	Domain
A [auth B], B [auth A]	IPR001841	Zinc finger, RING-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: Q86YT6	astrocytic tumor esophageal squamous cell carcinoma malignant ependymoma osteosarcoma atypical teratoid rhabdoid tumor glioblastoma malignant glioma ovarian cancer breast cancer large cell medulloblastoma malignant mesothelioma plasma cell myeloma left ventricular noncompaction left ventricular noncompaction 7 visual epilepsy astrocytic tumor esophageal squamous cell carcinoma malignant ependymoma osteosarcoma atypical teratoid rhabdoid tumor glioblastoma malignant glioma ovarian cancer breast cancer large cell medulloblastoma malignant mesothelioma plasma cell myeloma left ventricular noncompaction left ventricular noncompaction 7 visual epilepsy Gustatory seizure malignant pancreatic neoplasm myopathy ovarian cancer Crohn disease rheumatoid arthritis gastric cancer hepatocellular carcinoma juvenile dermatomyositis medulloblastoma acute myeloid leukemia atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma diabetes mellitus gastric carcinoma glioblastoma intellectual disability large cell medulloblastoma malignant ependymoma non-small cell lung carcinoma amyotrophic lateral sclerosis cardiomyopathy osteosarcoma Pick disease Emery-Dreifuss muscular dystrophy exocrine pancreatic carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.