8VY2 | pdb_00008vy2

Structure of mCELSR1 extracellular region containing CADH9-GAIN domains

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cadherin EGF LAG seven-pass G-type receptor 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity	protein localization localization cellular localization apical protein localization cellular macromolecule localization macromolecule localization cellular process behavior multicellular organismal process locomotory behavior developmental process establishment of planar polarity epithelium development morphogenesis of an epithelium protein localization localization cellular localization apical protein localization cellular macromolecule localization macromolecule localization cellular process behavior multicellular organismal process locomotory behavior developmental process establishment of planar polarity epithelium development morphogenesis of an epithelium tissue development anatomical structure morphogenesis tissue morphogenesis establishment of tissue polarity morphogenesis of a polarized epithelium anatomical structure development protein localization involved in establishment of planar polarity ear morphogenesis embryonic organ morphogenesis ear development sensory organ development animal organ development embryonic morphogenesis embryo development multicellular organism development sensory organ morphogenesis inner ear development inner ear morphogenesis animal organ morphogenesis embryonic organ development regulation of cytoskeleton organization regulation of biological process regulation of cellular component organization regulation of cellular process regulation of actin filament-based process actin cytoskeleton organization biological regulation regulation of organelle organization cellular component organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization epidermis development molting cycle process hair cycle skin development skin epidermis development hair follicle development molting cycle hair cycle process branching morphogenesis of an epithelial tube respiratory tube development lateral sprouting from an epithelium tube morphogenesis lung morphogenesis lung development respiratory system development epithelial tube morphogenesis system development tube development lateral sprouting involved in lung morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium neuron migration cellular developmental process nervous system development motor neuron migration generation of neurons neurogenesis cell differentiation cell migration cell motility embryonic epithelial tube formation chordate embryonic development tube formation epithelial tube formation primary neural tube formation embryo development ending in birth or egg hatching morphogenesis of embryonic epithelium neural tube development neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure establishment of planar polarity of embryonic epithelium cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling signal transduction cell communication planar dichotomous subdivision of terminal units involved in lung branching morphogenesis dichotomous subdivision of terminal units involved in lung branching dichotomous subdivision of an epithelial terminal unit orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis wound healing response to stress response to wounding establishment of body hair or bristle planar orientation establishment of body hair planar orientation cell adhesion cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules small GTPase-mediated signal transduction Rho protein signal transduction intracellular signal transduction intracellular signaling cassette anterior/posterior pattern specification pattern specification process regionalization	cellular anatomical structure membrane cell periphery plasma membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle cellular anatomical structure membrane cell periphery plasma membrane membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
A	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A	IPR000832	GPCR, family 2, secretin-like	Family
A	IPR000203	GPS motif	Conserved Site
A	IPR002049	Laminin-type EGF domain	Domain
A	IPR000742	EGF-like domain	Domain
A	IPR017981	GPCR, family 2-like, 7TM	Domain
A	IPR001791	Laminin G domain	Domain
A	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain
A	IPR020894	Cadherin conserved site	Conserved Site
A	IPR056286	CELSR1-3-like, ninth cadherin domain	Domain
A	IPR032471	AGRL2-4 , GAIN subdomain A	Domain
A	IPR009030	Growth factor receptor cysteine-rich domain superfamily	Homologous Superfamily
A	IPR001881	EGF-like calcium-binding domain	Domain
A	IPR046338	GAIN domain superfamily	Homologous Superfamily
A	IPR000152	EGF-type aspartate/asparagine hydroxylation site	PTM
A	IPR002126	Cadherin-like	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.