Annotations: 8YTF

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Transcription cofactor vestigial-like protein 4	transcription factor binding transcription coregulator binding protein binding binding transcription coactivator binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular response to stimulus response to stimulus negative regulation of signaling signaling regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth cellular component organization negative regulation of growth cellular component organization or biogenesis multicellular organismal process regulation of cardiac muscle tissue growth regulation of developmental process developmental growth cardiac muscle cell proliferation negative regulation of cardiac muscle tissue growth organ growth striated muscle tissue development negative regulation of organ growth multicellular organism development regulation of organ growth regulation of heart growth anatomical structure development regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development system development striated muscle cell proliferation developmental process heart development negative regulation of cell population proliferation heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development negative regulation of developmental process animal organ development tissue development circulatory system development negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation hippo signaling negative regulation of intracellular signal transduction intracellular signal transduction regulation of intracellular signal transduction negative regulation of hippo signaling regulation of hippo signaling catabolic process positive regulation of protein metabolic process positive regulation of biological process macromolecule catabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of protein metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of protein catabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
A	Interferon regulatory factor 2-binding protein 2	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding binding metal ion binding small molecule binding	regulation of cellular process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process regulation of cellular process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process developmental process multicellular organismal process cellular developmental process immature B cell differentiation hemopoiesis B cell activation cell activation cell development mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation cell differentiation immune system process anatomical structure development leukocyte differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR028184	Transcription cofactor vestigial-like protein 4	Family
B	IPR006627	TDU repeat	Repeat
A	IPR022750	Interferon regulatory factor 2-binding protein 1 & 2, zinc finger	Domain
A	IPR044882	Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q14135	Alzheimer disease endogenous depression lung cancer pancreatic ductal adenocarcinoma Pick disease subependymal giant cell astrocytoma astrocytic tumor glioblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer chronic obstructive pulmonary disease lung adenocarcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Alzheimer disease endogenous depression lung cancer pancreatic ductal adenocarcinoma Pick disease subependymal giant cell astrocytoma astrocytic tumor glioblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer chronic obstructive pulmonary disease lung adenocarcinoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis
A	Pharos: Q7Z5L9	acute promyelocytic leukemia atypical teratoid rhabdoid tumor immunodeficiency, common variable, 14 malignant ependymoma medulloblastoma ovarian cancer primitive neuroectodermal tumor Alzheimer disease breast carcinoma juvenile dermatomyositis malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma psoriasis astrocytic tumor acute promyelocytic leukemia atypical teratoid rhabdoid tumor immunodeficiency, common variable, 14 malignant ependymoma medulloblastoma ovarian cancer primitive neuroectodermal tumor Alzheimer disease breast carcinoma juvenile dermatomyositis malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma psoriasis astrocytic tumor glioblastoma large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma Pick disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.