Download MendeleyIRF2BP2 recognizes and bind to a conserved RxSVI sequence motif of protein partners and interacts with ZBTB16 to regulate megakaryocytic differentiation
Wang, G.C., Ding, J.P.To be published.
8YTF
Crystal structures of human IRF2BP2 RING domain in complex with VGLL4 peptide
- PDB DOI: https://doi.org/10.2210/pdb8YTF/pdb
- Classification: TRANSCRIPTION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-03-25 Released: 2024-11-20
- Funding Organization(s): Chinese Academy of Sciences
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.59 ?
- R-Value Free: 0.173
- R-Value Work: 0.153
- R-Value Observed: 0.154
Starting Model: in silico
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wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Interferon regulatory factor 2-binding protein 2 | 83 | Homo sapiens | Mutation(s): 0 Gene Names: IRF2BP2 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q7Z5L9 (Homo sapiens) Explore Q7Z5L9 Go to UniProtKB: Q7Z5L9 | |||||
PHAROS: Q7Z5L9 GTEx: ENSG00000168264 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q7Z5L9 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Transcription cofactor vestigial-like protein 4 | 8 | Homo sapiens | Mutation(s): 0 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q14135 (Homo sapiens) Explore Q14135 Go to UniProtKB: Q14135 | |||||
PHAROS: Q14135 GTEx: ENSG00000144560 | |||||
Entity Groups | |||||
| UniProt Group | Q14135 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| ZN (Subject of Investigation/LOI) Query on ZN | C [auth A], D [auth A], E [auth A] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.59 ?
- R-Value Free: 0.173
- R-Value Work: 0.153
- R-Value Observed: 0.154
- Space Group: P 21 21 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 33.372 | ¦Á = 90 |
| b = 43.209 | ¦Â = 90 |
| c = 55.761 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data scaling |
| HKL-2000 | data reduction |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-11-20 Deposition Author(s): Wang, G.C., Ding, J.P.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Chinese Academy of Sciences | China | XDB37030305 |
Revision History (Full details and data files)
- Version 1.0: 2024-11-20
Type: Initial release
