Annotations: 9DZN

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8043744	3000403	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	beta-beta-alpha zinc fingers	8091444	3001077	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth A]	PF01853	MOZ/SAS family (MOZ_SAS)	MOZ/SAS family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	Histone H3K14	DNA binding protein-containing complex binding binding chromatin binding nucleic acid binding nucleosome binding nucleosomal DNA binding chromatin DNA binding protein heterodimerization activity protein binding protein dimerization activity structural molecule activity structural constituent of chromatin	regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis regulation of growth regulation of biological process regulation of cellular process regulation of cellular component organization biological regulation growth positive regulation of biological process positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular process cellular component organization or biogenesis positive regulation of cellular process	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome protein-containing complex protein-DNA complex nucleosome membrane-bounded organelle nucleus intracellular organelle cellular anatomical structure intracellular anatomical structure organelle euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome protein-containing complex protein-DNA complex nucleosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B [auth A]	Histone acetyltransferase KAT6A	protein-lysine-acetyltransferase activity catalytic activity, acting on a protein protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity histone acetyltransferase activity acetyltransferase activity histone H3K56 acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity protein-lysine-acetyltransferase activity catalytic activity, acting on a protein protein N-acetyltransferase activity N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity histone acetyltransferase activity acetyltransferase activity histone H3K56 acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity histone H3K122 acetyltransferase activity histone H3K9 acetyltransferase activity DNA binding binding nucleic acid binding histone H3K27 acetyltransferase activity histone H4K12 acetyltransferase activity histone H4 acetyltransferase activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity histone H4K8 acetyltransferase activity chromatin binding transcription coactivator activity histone H3K4 acetyltransferase activity histone H3K14 acetyltransferase activity histone H3K18 acetyltransferase activity histone H2B acetyltransferase activity histone H2BK12 acetyltransferase activity histone H2AK9 acetyltransferase activity histone H2A acetyltransferase activity transcription factor binding protein binding DNA-binding transcription factor binding histone H2AK5 acetyltransferase activity histone H4K5 acetyltransferase activity histone H2BK5 acetyltransferase activity histone H4K16 acetyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding histone H3K36 acetyltransferase activity histone H3K23 acetyltransferase activity	regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process developmental process multicellular organismal process regulation of multicellular organismal development regulation of developmental process cellular developmental process hemopoiesis cell development regulation of cell differentiation regulation of cell development multicellular organism development cell differentiation immune system process anatomical structure development regulation of hemopoiesis regulation of immune system process regulation of multicellular organismal process cellular response to stimulus cellular response to stress response to stimulus response to stress cellular senescence RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of DNA-templated transcription myeloid cell differentiation negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process cellular component organization organelle organization chromosome organization cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling nucleosome assembly nucleosome organization protein acetylation macromolecule modification protein metabolic process protein modification process protein acylation positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of signaling signaling regulation of signal transduction signal transduction by p53 class mediator intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of signal transduction by p53 class mediator regulation of cell communication signal transduction transcription by RNA polymerase II regulation of transcription by RNA polymerase II	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol membraneless organelle intracellular membraneless organelle chromatin chromosome nucleolus protein-containing complex protein-DNA complex nucleosome catalytic complex MOZ/MORF histone acetyltransferase complex transferase complex H3 histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR009072	Histone-fold	Homologous Superfamily
A [auth C]	IPR007125	Histone H2A/H2B/H3	Domain
A [auth C]	IPR000164	Histone H3/CENP-A	Family
B [auth A]	IPR001965	Zinc finger, PHD-type	Domain
B [auth A]	IPR050603	MYST family histone acetyltransferases	Family
B [auth A]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
B [auth A]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B [auth A]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B [auth A]	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
B [auth A]	IPR005818	Linker histone H1/H5, domain H15	Domain
B [auth A]	IPR040706	MYST, zinc finger domain	Domain
B [auth A]	IPR002717	Histone acetyltransferase domain, MYST-type	Domain
B [auth A]	IPR019787	Zinc finger, PHD-finger	Domain
B [auth A]	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
B [auth A]	IPR048589	SAM domain-containing protein 1-like, WH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C]	Pharos: Q6NXT2	acute myeloid leukemia diabetes mellitus
B [auth A]	Pharos: Q92794	medulloblastoma autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome prostate cancer salivary gland adenoid cystic carcinoma intellectual disability medullomyoblastoma with myogenic differentiation adenoid cystic carcinoma melanotic medulloblastoma adult medulloblastoma childhood medulloblastoma MENTAL RETARDATION, AUTOSOMAL DOMINANT 32 acute myeloid leukemia with t(8;16)(p11;p13) translocation astrocytic tumor breast cancer craniosynostosis medulloblastoma autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome prostate cancer salivary gland adenoid cystic carcinoma intellectual disability medullomyoblastoma with myogenic differentiation adenoid cystic carcinoma melanotic medulloblastoma adult medulloblastoma childhood medulloblastoma MENTAL RETARDATION, AUTOSOMAL DOMINANT 32 acute myeloid leukemia with t(8;16)(p11;p13) translocation astrocytic tumor breast cancer craniosynostosis malignant mesothelioma ovarian cancer tuberculosis atypical teratoid rhabdoid tumor cancer desmoplastic/nodular medulloblastoma large cell medulloblastoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma psoriasis glioblastoma lung cancer

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B [auth A]	ALY	Parent Component: LYS RESID: AA0055 PSI-MOD : N6-acetyl-L-lysine MOD:00064

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.