9HJ8 | pdb_00009hj8

TRPML1 in complex with compound 5

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Mucolipin-1	monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity potassium ion transmembrane transporter activity potassium channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic cation channel activity passive transmembrane transporter activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity potassium ion transmembrane transporter activity potassium channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity metal ion transmembrane transporter activity calcium channel activity gated channel activity ligand-gated channel activity ligand-gated monoatomic ion channel activity calcium ion transmembrane transporter activity ligand-gated calcium channel activity ligand-gated monoatomic cation channel activity monoatomic anion transmembrane transporter activity monoatomic anion channel activity iron ion transmembrane transporter activity transition metal ion transmembrane transporter activity binding lipid binding sodium channel activity sodium ion transmembrane transporter activity intracellularly ligand-gated monoatomic ion channel activity NAADP-sensitive calcium-release channel activity intracellularly gated calcium channel activity intracellularly phosphatidylinositol-3,5-bisphosphate-gated monatomic cation channel activity identical protein binding protein binding	response to stimulus immune response immune system process adaptive immune response cellular component disassembly catabolic process protein-containing complex organization macroautophagy autophagy protein-containing complex disassembly cellular component organization autophagosome maturation cellular process metabolic process response to stimulus immune response immune system process adaptive immune response cellular component disassembly catabolic process protein-containing complex organization macroautophagy autophagy protein-containing complex disassembly cellular component organization autophagosome maturation cellular process metabolic process cellular component organization or biogenesis process utilizing autophagic mechanism protein homotetramerization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly protein homooligomerization cellular response to stimulus response to pH cellular response to pH response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus organelle organization phagosome maturation localization transport monoatomic ion transport monoatomic cation transport establishment of localization cellular response to metal ion cellular response to chemical stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion monoatomic ion transmembrane transport inorganic ion transmembrane transport calcium ion transport metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport calcium ion transmembrane transport regulation of localization cellular localization regulation of cellular process inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process negative regulation of biological process calcium ion homeostasis negative regulation of sequestering of calcium ion maintenance of location in cell intracellular monoatomic cation homeostasis monoatomic ion homeostasis negative regulation of cellular process intracellular chemical homeostasis monoatomic cation homeostasis regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis regulation of biological process calcium ion transmembrane import into cytosol sequestering of calcium ion biological regulation maintenance of location release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis iron ion transport iron ion transmembrane transport transition metal ion transport calcium ion export positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization vacuole organization lytic vacuole organization positive regulation of vacuole organization positive regulation of biological process regulation of vacuole organization regulation of organelle organization lysosome organization regulation of lysosome organization positive regulation of lysosome organization positive regulation of cellular process protein localization establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization transferrin transport	cellular anatomical structure membrane cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cellular anatomical structure membrane cell periphery plasma membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome cytoplasm vesicle organelle membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen lytic vacuole vacuole lysosome protein-containing complex receptor complex phagocytic vesicle phagocytic vesicle membrane endocytic vesicle membrane endocytic vesicle vacuolar membrane lytic vacuole membrane lysosomal membrane Golgi apparatus phagocytic cup cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR047316	Mucolipin-1, extracytosolic/lumenal domain	Domain
A, B, C, D	IPR049134	Mucolipin, extracytosolic domain	Domain
A, B, C, D	IPR039031	Mucolipin	Family
A, B, C, D	IPR013122	Polycystin cation channel, PKD1/PKD2	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q9GZU1	mucolipidosis type IV sialidosis type 2 lysosomal storage disease gangliosidosis intellectual disability Malignant neoplasm of breast leukodystrophy mucolipidosis inborn errors of metabolism mucolipidosis type II sialidosis type 1

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.