Annotations: 9LKX

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth J]	PF12796	Ankyrin repeats (3 copies) (Ank_2)	Ankyrin repeats (3 copies)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth J]	Protein fem-1 homolog B	protein binding binding signaling receptor binding cytokine receptor binding tumor necrosis factor receptor superfamily binding death receptor binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity cation binding ion binding metal ion binding small molecule binding	catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process catabolic process ubiquitin-dependent protein catabolic process via the C-end degron rule pathway proteolysis involved in protein catabolic process primary metabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process cellular process macromolecule metabolic process protein metabolic process multicellular organismal process prostate gland development reproductive process gland development developmental process involved in reproduction prostate gland epithelium morphogenesis multicellular organism development gland morphogenesis anatomical structure development reproductive structure development animal organ morphogenesis system development developmental process epithelium development reproductive system development animal organ development morphogenesis of an epithelium urogenital system development tissue development prostate gland morphogenesis tissue morphogenesis anatomical structure morphogenesis morphogenesis of a branching structure branching involved in prostate gland morphogenesis morphogenesis of a branching epithelium apoptotic process cell death programmed cell death cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors regulation of cellular process response to stimulus signaling regulation of signal transduction regulation of programmed cell death extrinsic apoptotic signaling pathway cell communication signal transduction regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of apoptotic process biological regulation regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway via death domain receptors regulation of cell communication regulation of apoptotic signaling pathway protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal regulation of molecular function regulation of catalytic activity regulation of ubiquitin-protein transferase activity regulation of transferase activity DNA damage checkpoint signaling regulation of cell cycle phase transition negative regulation of biological process regulation of cellular response to stress negative regulation of cell cycle cell cycle phase transition intracellular signal transduction regulation of cell cycle checkpoint cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage regulation of DNA damage checkpoint epithelial cell maturation involved in prostate gland development cellular developmental process cell development epithelial cell differentiation cell differentiation cell maturation epithelial cell differentiation involved in prostate gland development developmental maturation epithelial cell development anatomical structure maturation epithelial cell maturation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex cullin-RING ubiquitin ligase complex Cul2-RING ubiquitin ligase complex
B [auth K]	Mitochondrial cardiolipin hydrolase	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity cardiolipin hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity endonuclease activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity cardiolipin hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters nuclease activity catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	positive regulation of organelle organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process cellular component organization positive regulation of developmental process anatomical structure development regulation of mitochondrial fusion cellular component organization or biogenesis mitochondrial fusion positive regulation of cellular process regulation of anatomical structure morphogenesis positive regulation of organelle organization regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization regulation of developmental process positive regulation of biological process cellular component organization positive regulation of developmental process anatomical structure development regulation of mitochondrial fusion cellular component organization or biogenesis mitochondrial fusion positive regulation of cellular process regulation of anatomical structure morphogenesis positive regulation of mitochondrial fusion mitochondrion organization developmental process regulation of biological process biological regulation regulation of organelle organization organelle fusion anatomical structure morphogenesis organelle organization regulation of mitochondrion organization cellular process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation cell differentiation germ cell development lipid catabolic process catabolic process metabolic process primary metabolic process lipid metabolic process piRNA processing negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process meiotic cell cycle cell cycle multicellular organismal process blastoderm segmentation anterior/posterior pattern specification anterior/posterior axis specification, embryo segmentation pattern specification process female gamete generation embryo development oocyte development tripartite regional subdivision cellular component biogenesis embryonic axis specification multicellular organism development cellular component assembly anterior/posterior axis specification cell maturation P granule organization embryonic pattern specification oocyte axis specification oocyte construction oogenesis oocyte anterior/posterior axis specification cytoplasm organization developmental maturation regionalization pole plasm assembly anatomical structure maturation maternal determination of anterior/posterior axis, embryo oocyte differentiation axis specification	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle Golgi apparatus endomembrane system mitochondrial membrane membrane organelle outer membrane organelle envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle Golgi apparatus endomembrane system mitochondrial membrane membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth J]	IPR002110	Ankyrin repeat	Repeat
A [auth J]	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
B [auth K]	IPR025202	Phospholipase D-like domain	Domain
B [auth K]	IPR001736	Phospholipase D/Transphosphatidylase	Domain
B [auth K]	IPR051406	Phospholipase D domain-containing protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth J]	Pharos: Q9UK73	tuberculosis astrocytic tumor dermatomyositis gastric carcinoma juvenile dermatomyositis malignant glioma medulloblastoma plantar fibromatosis atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma glioblastoma large cell medulloblastoma malignant mesothelioma myopathy plasma cell myeloma tuberculosis astrocytic tumor dermatomyositis gastric carcinoma juvenile dermatomyositis malignant glioma medulloblastoma plantar fibromatosis atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma glioblastoma large cell medulloblastoma malignant mesothelioma myopathy plasma cell myeloma breast cancer gastric cancer hepatocellular carcinoma malignant colon neoplasm malignant pancreatic neoplasm ovarian cancer
B [auth K]	Pharos: Q8N2A8	exocrine pancreatic carcinoma malignant pancreatic neoplasm osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.