9CAL

Human TOP3B-TDRD3 core complex in post-cleavage state with ssDNA 5'-ACAGATATT-3

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01131	DNA topoisomerase (Topoisom_bac)	DNA topoisomerase	-	Family
A	PF01751	Toprim domain (Toprim)	Toprim domain	-	Family
B	PF08585	RMI1, N-terminal OB-fold domain (RMI1_N_C)	RMI1, N-terminal OB-fold domain	This is the OB-fold domain found at the N-terminal of RecQ-mediated genome instability protein 1 (RMI1), which forms a stable complex with Bloom syndrome protein BLM and DNA topoisomerase 3-alpha [1-3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA topoisomerase 3-beta-1	DNA binding binding nucleic acid binding RNA topoisomerase activity isomerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid catalytic activity DNA topoisomerase type I (single strand cut, ATP-independent) activity catalytic activity, acting on DNA DNA topoisomerase activity RNA binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair cell cycle chromosome segregation cell cycle process chromosome organization DNA conformation change cellular component organization DNA topological change organelle organization cellular component organization or biogenesis DNA recombination	protein-containing complex DNA topoisomerase III-beta-TDRD3 complex intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome condensed chromosome membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B	Tudor domain-containing protein 3	chromatin binding binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity RNA binding nucleic acid binding methylated histone binding protein binding modification-dependent protein binding histone binding methylation-dependent protein binding	chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process DNA topological change organelle organization cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process chromatin organization	protein-containing complex DNA topoisomerase III-beta-TDRD3 complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cytosol nucleus membrane-enclosed lumen protein-containing complex DNA topoisomerase III-beta-TDRD3 complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system cytosol nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C [auth D]	DNA (5'-D(PGPAPCPAPGPAP*T)-3')	-	-	-
D [auth E]	DNA (5'-D(APTP*T)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013497	DNA topoisomerase, type IA, central	Domain
A	IPR003602	DNA topoisomerase, type IA, DNA-binding domain	Domain
A	IPR023405	DNA topoisomerase, type IA, core domain	Homologous Superfamily
A	IPR013825	DNA topoisomerase, type IA, central region, subdomain 2	Homologous Superfamily
A	IPR003601	DNA topoisomerase, type IA, domain 2	Domain
A	IPR000380	DNA topoisomerase, type IA	Family
A	IPR013826	DNA topoisomerase, type IA, central region, subdomain 3	Homologous Superfamily
A	IPR006171	TOPRIM domain	Domain
A	IPR023406	DNA topoisomerase, type IA, active site	Active Site
A	IPR034144	DNA topoisomerase 3-like, TOPRIM domain	Domain
A	IPR013824	DNA topoisomerase, type IA, central region, subdomain 1	Homologous Superfamily
B	IPR002999	Tudor domain	Domain
B	IPR047379	Tudor domain-containing protein 3, Tudor domain	Domain
B	IPR013894	RecQ mediated genome instability protein 1, OB-fold domain	Domain
B	IPR042470	RecQ mediated genome instability protein, N-terminal OB-fold domain superfamily	Homologous Superfamily
B	IPR041915	Tudor domain-containing protein 3, UBA domain	Domain
B	IPR009060	UBA-like superfamily	Homologous Superfamily
B	IPR015940	Ubiquitin-associated domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95985	schizophrenia
B	Pharos: Q9H7E2	lung cancer ovarian cancer medulloblastoma psoriasis osteosarcoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.