Paper Published: Impact of the PDB on drug approvals

02/21 

Figure 3: Tazemetostat inhibition of EZH2
(2024) Oncogene 43: 2229–2243 doi: 10.1038/s41388-024-03077-2

Open access to the PDB facilitated discovery/development of 100% of the 34 new low molecular weight, protein-targeted, antineoplastic agents approved by the US FDA 2019–2023.

In addition to aggregate impact assessments, illustrative case studies are presented for six first-in-class small-molecule anti-cancer drugs.

Impact of structural biology and the Protein Data Bank on US FDA new drug approvals of low molecular weight antineoplastic agents 2019–2023
Stephen K. Burley, Amy Wu-Wu, Shuchismita Dutta, Shridar Ganesan & Steven X. F. Zheng
(2024) Oncogene 43: 2229–2243 doi: 10.1038/s41388-024-03077-2

News Index

• 02/21 Paper Published: Impact of the PDB on drug approvals

• 02/17 Register Now for Webinar on API Access with Python

• 02/17 PDB-101 Focus: Peak Performance

• 02/13 Meet RCSB PDB at The Biophysical Society Meeting

• 02/10 Register for the March 13 Virtual Office Hour on Supporting Extended PDB IDs

• 02/09 Molecular Valentines

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• 02/01 February 4 is World Cancer Day

• 01/28 Frontiers in Data Panel Webinar: Preparing Structural Science Data for 2085

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• 01/19 January is Cervical Cancer Awareness Month

• 01/17 Undergrads: Spend your summer with RCSB PDB

• 01/16 wwPDB News: PDB-Dev now PDB-IHM

• 01/16 Top Molecules of the Month in 2024

• 01/14 Winter Newsletter Published

• 01/12 Paper Published: Updated resources for exploring PDB structures and Computed Structure Models

• 01/09 Celebrate #NationalMilkDay

• 01/05 Molecule of the Month: Celebrating 25 Years of Storytelling and Announcing New Beginnings

• 01/05 wwPDB News: Time-stamped Copies of PDB and EMDB Archives