Download MendeleyHuman Type I 17Beta-Hydroxysteroid Dehydrogenase: Site Directed Mutagenesis and X-Ray Crystallography Structure-Function Analysis
Mazza, C.(1997) Thesis
1A27
HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 C-TERMINAL DELETION MUTANT COMPLEXED WITH ESTRADIOL AND NADP+
- PDB DOI: https://doi.org/10.2210/pdb1A27/pdb
- Classification: DEHYDROGENASE
- Organism(s): Homo sapiens
- Expression System: unidentified baculovirus
- Mutation(s): No
- Deposited: 1998-01-16 Released: 1998-05-27
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 ?
- R-Value Free: 0.261
- R-Value Work: 0.210
Starting Model: experimental
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This is version 1.6 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | 289 | Homo sapiens | Mutation(s): 0 EC: 1.1.1.62 (PDB Primary Data), 1.1.1.51 (UniProt) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P14061 (Homo sapiens) Explore P14061 Go to UniProtKB: P14061 | |||||
PHAROS: P14061 GTEx: ENSG00000108786 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P14061 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAP Query on NAP | C [auth A] | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE C21 H28 N7 O17 P3 XJLXINKUBYWONI-NNYOXOHSSA-N |  | ||
| EST Query on EST | B [auth A] | ESTRADIOL C18 H24 O2 VOXZDWNPVJITMN-ZBRFXRBCSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 ?
- R-Value Free: 0.261
- R-Value Work: 0.210
- Space Group: C 1 2 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 111.38 | ¦Á = 90 |
| b = 48.54 | ¦Â = 115.13 |
| c = 60.77 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| AMoRE | phasing |
| REFMAC | refinement |
| XDS | data reduction |
Entry History
Deposition Data
- Released Date: 1998-05-27 Deposition Author(s): Mazza, C., Breton, R., Housset, D., Fontecilla-Camps, J.-C.
Revision History (Full details and data files)
- Version 1.0: 1998-05-27
Type: Initial release - Version 1.1: 2008-03-24
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Derived calculations, Version format compliance - Version 1.3: 2018-04-04
Changes: Advisory, Data collection - Version 1.4: 2018-04-11
Changes: Data collection - Version 1.5: 2023-08-02
Changes: Advisory, Database references, Derived calculations, Refinement description - Version 1.6: 2024-05-22
Changes: Data collection
