Download MendeleyRole of Sa-Hd Loop Movement in Cortisol Release Mechanism of Cbg
Chan, W.L., Zhou, A., Read, R.J.To be published.
4C49
Reactive loop cleaved human CBG in complex with cortisol
- PDB DOI: https://doi.org/10.2210/pdb4C49/pdb
- Classification: TRANSPORT PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): Yes
- Deposited: 2013-09-02 Released: 2014-10-01
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 ?
- R-Value Free: 0.268
- R-Value Work: 0.221
- R-Value Observed: 0.223
Starting Model: experimental
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This is version 2.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| CORTICOSTEROID-BINDING GLOBULIN | 373 | Homo sapiens | Mutation(s): 1 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P08185 (Homo sapiens) Explore P08185 Go to UniProtKB: P08185 | |||||
PHAROS: P08185 GTEx: ENSG00000170099 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P08185 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| HCY Query on HCY | E [auth A], F [auth B], G [auth C], H [auth D] | (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione C21 H30 O5 JYGXADMDTFJGBT-VWUMJDOOSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.70 ?
- R-Value Free: 0.268
- R-Value Work: 0.221
- R-Value Observed: 0.223
- Space Group: P 1 21 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 72.82 | ¦Á = 90 |
| b = 110.42 | ¦Â = 102.52 |
| c = 92.54 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| MOSFLM | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2014-10-01 Deposition Author(s): Chan, W.L., Zhou, A., Read, R.J.
Revision History (Full details and data files)
- Version 1.0: 2014-10-01
Type: Initial release - Version 2.0: 2023-12-20
Changes: Atomic model, Data collection, Database references, Derived calculations, Other, Refinement description - Version 2.1: 2024-11-06
Changes: Structure summary
