A structural basis for streptomycin resistance
Demirci, H., Murphy IV, F., Murphy, E., Gregory, S.T., Dahlberg, A.E., Jogl, G.To be published.
Experimental Data Snapshot
Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S2 | 256 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P80371 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P80371  Go to UniProtKB:  P80371 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P80371 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 3 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S3 | 239 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P80372 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P80372  Go to UniProtKB:  P80372 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P80372 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 4 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S4 | 209 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P80373 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P80373  Go to UniProtKB:  P80373 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P80373 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 5 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S5 | 162 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SHQ5 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SHQ5  Go to UniProtKB:  Q5SHQ5 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SHQ5 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 6 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S6 | 101 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SLP8 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SLP8  Go to UniProtKB:  Q5SLP8 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SLP8 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 7 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S7 | 156 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P17291 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P17291  Go to UniProtKB:  P17291 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P17291 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 8 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S8 | 138 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P0DOY9 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P0DOY9  Go to UniProtKB:  P0DOY9 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P0DOY9 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 9 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S9 | 128 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P80374 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P80374  Go to UniProtKB:  P80374 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P80374 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 10 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S10 | 105 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SHN7 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SHN7  Go to UniProtKB:  Q5SHN7 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SHN7 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 11 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S11 | 129 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P80376 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P80376  Go to UniProtKB:  P80376 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P80376 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 12 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S12 | 135 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SHN3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SHN3  Go to UniProtKB:  Q5SHN3 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SHN3 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 13 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S13 | 126 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P80377 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P80377  Go to UniProtKB:  P80377 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P80377 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 14 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S14 | 61 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P0DOY6 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P0DOY6  Go to UniProtKB:  P0DOY6 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P0DOY6 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 15 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S15 | 89 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SJ76 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SJ76  Go to UniProtKB:  Q5SJ76 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SJ76 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 16 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S16 | 88 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SJH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SJH3  Go to UniProtKB:  Q5SJH3 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SJH3 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 17 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S17 | 105 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P0DOY7 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P0DOY7  Go to UniProtKB:  P0DOY7 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P0DOY7 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 18 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S18 | 88 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SLQ0 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SLQ0  Go to UniProtKB:  Q5SLQ0 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SLQ0 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 19 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S19 | 93 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SHP2 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SHP2  Go to UniProtKB:  Q5SHP2 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SHP2 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 20 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein S20 | 106 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for P80380 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore P80380  Go to UniProtKB:  P80380 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P80380 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 21 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
ribosomal protein THX | 27 | Thermus thermophilus HB8 | Mutation(s): 0  | ||
UniProt | |||||
Find proteins for Q5SIH3 (Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)) Explore Q5SIH3  Go to UniProtKB:  Q5SIH3 | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | Q5SIH3 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Length | Organism | Image | |
16S rRNA | 1,522 | Thermus thermophilus HB8 | |||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
SRY Query on SRY | V [auth A] | STREPTOMYCIN C21 H39 N7 O12 UCSJYZPVAKXKNQ-HZYVHMACSA-N | |||
ZN Query on ZN | KK [auth N], XJ [auth D] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N | |||
MG Query on MG | AA [auth A] AB [auth A] AC [auth A] AD [auth A] AE [auth A] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |
Modified Residues 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Type | Formula | 2D Diagram | Parent |
0TD Query on 0TD | L | L-PEPTIDE LINKING | C5 H9 N O4 S | ASP |
Length ( ? ) | Angle ( ? ) |
---|---|
a = 402.977 | ¦Á = 90 |
b = 402.977 | ¦Â = 90 |
c = 172.607 | ¦Ã = 90 |
Software Name | Purpose |
---|---|
DENZO | data reduction |
SCALEPACK | data scaling |
PHENIX | refinement |
PDB_EXTRACT | data extraction |
HKL-2000 | data collection |
PHENIX | phasing |