Download MendeleyHigh Resolution Structures of Viral Neuraminidase with Drugs Bound in the Active Site. (In preparation)
Salinger, M.T., Hobbs, J.R., Murray, J.W., Laver, W.G., Kuhn, P., Garman, E.F.To be published.
6HFC
Influenza A Virus N9 Neuraminidase Native (Tern).
- PDB DOI: https://doi.org/10.2210/pdb6HFC/pdb
- Classification: HYDROLASE
- Organism(s): Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
- Mutation(s): No
- Deposited: 2018-08-21 Released: 2018-08-29
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.29 ?
- R-Value Free: 0.164
- R-Value Work: 0.141
- R-Value Observed: 0.142
Starting Model: experimental
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wwPDB Validation 3D Report Full Report
This is version 2.3 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Neuraminidase | 388 | Influenza A virus (A/tern/Australia/G70C/1975(H11N9)) | Mutation(s): 0 EC: 3.2.1.18 |  | |
UniProt | |||||
Find proteins for P03472 (Influenza A virus (strain A/Tern/Australia/G70C/1975 H11N9)) Explore P03472 Go to UniProtKB: P03472 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P03472 | ||||
Glycosylation | |||||
| Glycosylation Sites: 3 | |||||
Sequence AnnotationsExpand | |||||
| |||||
Oligosaccharides
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
| alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | B | 10 |  | N-Glycosylation | |
Glycosylation Resources | |||||
GlyTouCan: G40702WU GlyCosmos: G40702WU GlyGen: G40702WU | |||||
Small Molecules
| Ligands 5 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PO4 Query on PO4 | Q [auth A] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
| GOL Query on GOL | G [auth A] H [auth A] I [auth A] J [auth A] K [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| CO2 Query on CO2 | P [auth A] | CARBON DIOXIDE C O2 CURLTUGMZLYLDI-UHFFFAOYSA-N |  | ||
| CA Query on CA | E [auth A], F [auth A] | CALCIUM ION Ca BHPQYMZQTOCNFJ-UHFFFAOYSA-N |  | ||
| K Query on K | N [auth A], O [auth A] | POTASSIUM ION K NPYPAHLBTDXSSS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.29 ?
- R-Value Free: 0.164
- R-Value Work: 0.141
- R-Value Observed: 0.142
- Space Group: I 4 3 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 180 | α = 90 |
| b = 180 | β = 90 |
| c = 180 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
| REFMAC | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2018-08-29 Deposition Author(s): Salinger, M.T., Hobbs, J.R., Murray, J.W., Laver, W.G., Kuhn, P., Garman, E.F.
| Funding Organization | Location | Grant Number |
|---|---|---|
| United Kingdom | -- |
Revision History (Full details and data files)
- Version 1.0: 2018-08-29
Type: Initial release - Version 1.1: 2018-09-05
Changes: Data collection, Database references, Structure summary - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Atomic model, Data collection, Derived calculations, Structure summary - Version 2.1: 2023-03-15
Changes: Database references, Derived calculations, Structure summary - Version 2.2: 2024-02-07
Changes: Data collection, Refinement description - Version 2.3: 2024-11-13
Changes: Structure summary
