Download MendeleyFactor Inhibiting HIF (FIH) in complex with zinc, NOG and iASPP(670-693)
Leissing, T.M., Chowdhury, R., Clifton, I.J., Lu, X., Schofield, C.J.To be published.
6HL6
Factor Inhibiting HIF (FIH) in complex with zinc, NOG and iASPP(670-693)
- PDB DOI: https://doi.org/10.2210/pdb6HL6/pdb
- Classification: GENE REGULATION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2018-09-10 Released: 2019-10-09
- Funding Organization(s): Engineering and Physical Sciences Research Council
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.97 ?
- R-Value Free: 0.205
- R-Value Work: 0.171
- R-Value Observed: 0.172
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hypoxia-inducible factor 1-alpha inhibitor | 350 | Homo sapiens | Mutation(s): 0 Gene Names: HIF1AN, FIH1 EC: 1.14.11.30 (PDB Primary Data), 1.14.11 (PDB Primary Data) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9NWT6 (Homo sapiens) Explore Q9NWT6 Go to UniProtKB: Q9NWT6 | |||||
PHAROS: Q9NWT6 GTEx: ENSG00000166135 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9NWT6 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| RelA-associated inhibitor | B [auth S] | 24 | Homo sapiens | Mutation(s): 0 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8WUF5 (Homo sapiens) Explore Q8WUF5 Go to UniProtKB: Q8WUF5 | |||||
PHAROS: Q8WUF5 GTEx: ENSG00000104881 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8WUF5 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| OGA Query on OGA | L [auth A] | N-OXALYLGLYCINE C4 H5 N O5 BIMZLRFONYSTPT-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | H [auth A], I [auth A], J [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| GOL Query on GOL | C [auth A], D [auth A], E [auth A], F [auth A], G [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| ZN Query on ZN | K [auth A] | ZINC ION Zn PTFCDOFLOPIGGS-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.97 ?
- R-Value Free: 0.205
- R-Value Work: 0.171
- R-Value Observed: 0.172
- Space Group: P 41 21 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 86.084 | ¦Á = 90 |
| b = 86.084 | ¦Â = 90 |
| c = 148.752 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| xia2 | data reduction |
| xia2 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2019-10-09 Deposition Author(s): Leissing, T.M., Chowdhury, R., Clifton, I.J., Lu, X., Schofield, C.J.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Engineering and Physical Sciences Research Council | United Kingdom | P/G03706X/1 |
Revision History (Full details and data files)
- Version 1.0: 2019-10-09
Type: Initial release - Version 1.1: 2024-01-24
Changes: Data collection, Database references, Refinement description
