Download MendeleyS-adenosylmethionine synthetase
Laurino, P., Jackson, C.J., Tan, L.L.To be published.
6WKB
Human S-adenosylmethionine synthetase co-crystallized with UppNHp and Met
- PDB DOI: https://doi.org/10.2210/pdb6WKB/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2020-04-15 Released: 2021-04-21
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.55 ?
- R-Value Free: 0.266
- R-Value Work: 0.220
- R-Value Observed: 0.223
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| S-adenosylmethionine synthase isoform type-2 | 395 | Homo sapiens | Mutation(s): 0 Gene Names: MAT2A, AMS2, MATA2 EC: 2.5.1.6 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P31153 (Homo sapiens) Explore P31153 Go to UniProtKB: P31153 | |||||
PHAROS: P31153 GTEx: ENSG00000168906 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P31153 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| U4P Query on U4P | C [auth A], G [auth B] | 5'-deoxyuridine C9 H12 N2 O5 WUBAOANSQGKRHF-XVFCMESISA-N |  | ||
| MET Query on MET | F [auth B] | METHIONINE C5 H11 N O2 S FFEARJCKVFRZRR-BYPYZUCNSA-N |  | ||
| MED Query on MED | D [auth A] | D-METHIONINE C5 H11 N O2 S FFEARJCKVFRZRR-SCSAIBSYSA-N |  | ||
| EDO Query on EDO | E [auth B] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.55 ?
- R-Value Free: 0.266
- R-Value Work: 0.220
- R-Value Observed: 0.223
- Space Group: P 63 2 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 144.191 | ¦Á = 90 |
| b = 144.191 | ¦Â = 90 |
| c = 188.196 | ¦Ă = 120 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2021-04-21 Deposition Author(s): Tan, L.L., Jackson, C.J.
Revision History (Full details and data files)
- Version 1.0: 2021-04-21
Type: Initial release - Version 1.1: 2023-10-18
Changes: Data collection, Database references, Refinement description
