Download MendeleyNotum Fragment Screen
Zhao, Y., Jones, E.Y.To be published.
7B7W
Notum-Fragment049
- PDB DOI: https://doi.org/10.2210/pdb7B7W/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): Yes
- Deposited: 2020-12-11 Released: 2021-07-21
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 ?
- R-Value Free: 0.227
- R-Value Work: 0.205
- R-Value Observed: 0.206
Starting Model: experimental
View more details
This is version 1.2 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Palmitoleoyl-protein carboxylesterase NOTUM | 383 | Homo sapiens | Mutation(s): 1 Gene Names: NOTUM, OK/SW-CL.30 EC: 3.1.1.98 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q6P988 (Homo sapiens) Explore Q6P988 Go to UniProtKB: Q6P988 | |||||
PHAROS: Q6P988 GTEx: ENSG00000185269 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q6P988 | ||||
Glycosylation | |||||
| Glycosylation Sites: 1 | Go to GlyGen: Q6P988-1 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | C [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
| JGA (Subject of Investigation/LOI) Query on JGA | H [auth A] | N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea C7 H11 N3 O2 OLTOJZGRSVNYRB-UHFFFAOYSA-N |  | ||
| SO4 Query on SO4 | B [auth A], D [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| EDO Query on EDO | E [auth A], F [auth A], G [auth A] | 1,2-ETHANEDIOL C2 H6 O2 LYCAIKOWRPUZTN-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.60 ?
- R-Value Free: 0.227
- R-Value Work: 0.205
- R-Value Observed: 0.206
- Space Group: P 21 21 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 60.003 | ¦Á = 90 |
| b = 72.68 | ¦Â = 90 |
| c = 78.475 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| xia2 | data scaling |
| PDB_EXTRACT | data extraction |
| xia2 | data reduction |
| MOLREP | phasing |
Entry History
Deposition Data
- Released Date: 2021-07-21 Deposition Author(s): Zhao, Y., Jonees, E.Y.
Revision History (Full details and data files)
- Version 1.0: 2021-07-21
Type: Initial release - Version 1.1: 2024-01-31
Changes: Data collection, Database references, Refinement description - Version 1.2: 2024-11-20
Changes: Structure summary
