Download MendeleyX-ray structure of the human adipocyte fatty acid-binding protein complexed with the fluorescent probe HA728
Takahashi, J., Matsuoka, S., Tsuchikawa, H., Sonoyama, M., Inoue, Y., Hayashi, F., Murata, M., Sugiyama, S.To be published.
7WC3 | pdb_00007wc3
X-ray structure of the human adipocyte fatty acid-binding protein complexed with the fluorescent probe HA728
- PDB DOI: https://doi.org/10.2210/pdb7WC3/pdb
- Classification: LIPID BINDING PROTEIN
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2021-12-18 Released: 2022-12-21
- Funding Organization(s): Japan Society for the Promotion of Science (JSPS), Japan Science and Technology
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.50 ?
- R-Value Free: 0.175 (Depositor), 0.180 (DCC)
- R-Value Work: 0.123 (Depositor), 0.130 (DCC)
- R-Value Observed: 0.125 (Depositor)
Starting Model: experimental
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This is version 1.1 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Fatty acid-binding protein, adipocyte | 132 | Homo sapiens | Mutation(s): 0 Gene Names: FABP4 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P15090 (Homo sapiens) Explore P15090 Go to UniProtKB: P15090 | |||||
PHAROS: P15090 GTEx: ENSG00000170323 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P15090 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| 8QU (Subject of Investigation/LOI) Query on 8QU | B [auth A] | (3S)-1-(4-nitro-2,1,3-benzoxadiazol-7-yl)piperidine-3-carboxylic acid C12 H12 N4 O5 OUFPFDCBWRREOT-ZETCQYMHSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.50 ?
- R-Value Free: 0.175 (Depositor), 0.180 (DCC)
- R-Value Work: 0.123 (Depositor), 0.130 (DCC)
- R-Value Observed: 0.125 (Depositor)
Space Group: P 21 21 2
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 52.98 | ¦Á = 90 |
| b = 71.665 | ¦Â = 90 |
| c = 31.637 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| MOLREP | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2022-12-21 Deposition Author(s): Takahashi, J., Matsuoka, S., Tsuchikawa, H., Sonoyama, M., Inoue, Y., Hayashi, F., Murata, M., Sugiyama, S.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Japan Society for the Promotion of Science (JSPS) | Japan | 19K06588 |
| Japan Science and Technology | Japan | JPMJTM19DC |
| Japan Science and Technology | Japan | JPMJER1005 |
Revision History (Full details and data files)
- Version 1.0: 2022-12-21
Type: Initial release - Version 1.1: 2023-11-29
Changes: Data collection, Refinement description
