Download MendeleyCo-ordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate, IP8
Wang, H., Shears, S.To be published.
8TYV
Crystal structure of the SPX domain of XPR1 in complex with IP8
- PDB DOI: https://doi.org/10.2210/pdb8TYV/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2023-08-25 Released: 2024-06-12
- Funding Organization(s): National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 ?
- R-Value Free: 0.271
- R-Value Work: 0.236
- R-Value Observed: 0.238
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Solute carrier family 53 member 1 | A [auth B], B [auth A] | 181 | Homo sapiens | Mutation(s): 0 Gene Names: XPR1, SLC53A1, SYG1, X3 |  |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q9UBH6 (Homo sapiens) Explore Q9UBH6 Go to UniProtKB: Q9UBH6 | |||||
PHAROS: Q9UBH6 GTEx: ENSG00000143324 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q9UBH6 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| I8P (Subject of Investigation/LOI) Query on I8P | C [auth A] | (1R,3S,4R,5S,6R)-2,4,5,6-tetrakis(phosphonooxy)cyclohexane-1,3-diyl bis[trihydrogen (diphosphate)] C6 H20 O30 P8 HHQOOERQSFJGEP-SLWYWOEDSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.85 ?
- R-Value Free: 0.271
- R-Value Work: 0.236
- R-Value Observed: 0.238
- Space Group: P 1 21 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 56.712 | ¦Á = 90 |
| b = 47.754 | ¦Â = 104.21 |
| c = 70.373 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data scaling |
| HKL-2000 | data reduction |
| REFMAC | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2024-06-12 Deposition Author(s): Wang, H., Shears, S.B.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute of Environmental Health Sciences (NIH/NIEHS) | United States | 1ZIAES080046 |
Revision History (Full details and data files)
- Version 1.0: 2024-06-12
Type: Initial release
