Download MendeleyActivation mechanism of caseinolytic chaperone-protease system in Mycobacterium tuberculosis by the anti-cancer drug bortezomib
Zhou, B., Gao, Y., Zhao, H., Chen, X., He, J., Zhang, T., Xiong, X.To be published.
8YD4
CryoEM structure of apo M. tuberculosis ClpP1P2
- PDB DOI: https://doi.org/10.2210/pdb8YD4/pdb
- EM Map EMD-39164: EMDB EMDataResource
- Classification: HYDROLASE
- Organism(s): Mycobacterium tuberculosis H37Rv
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2024-02-19 Released: 2025-02-12
- Funding Organization(s): Other government, National Natural Science Foundation of China (NSFC)
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 3.69 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| ATP-dependent Clp protease proteolytic subunit 1 | 200 | Mycobacterium tuberculosis H37Rv | Mutation(s): 0 Gene Names: clpP1 EC: 3.4.21.92 |  | |
UniProt | |||||
Find proteins for P9WPC5 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WPC5 Go to UniProtKB: P9WPC5 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P9WPC5 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| ATP-dependent Clp protease proteolytic subunit 2 | 214 | Mycobacterium tuberculosis H37Rv | Mutation(s): 0 Gene Names: clpP2 EC: 3.4.21.92 |  | |
UniProt | |||||
Find proteins for P9WPC3 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WPC3 Go to UniProtKB: P9WPC3 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P9WPC3 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 3.69 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
| Task | Software Package | Version |
|---|---|---|
| MODEL REFINEMENT | PHENIX | 1.17.1_3660: |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-02-12 Deposition Author(s): Zhou, B., Gao, Y., Zhao, H., Chen, X., He, J., Zhang, T., Xiong, X.
| Funding Organization | Location | Grant Number |
|---|---|---|
| Other government | 2021YFA1300903 | |
| Other government | 2021YFA1300904 | |
| National Natural Science Foundation of China (NSFC) | China | 32300152 |
| National Natural Science Foundation of China (NSFC) | China | 81973372 |
| National Natural Science Foundation of China (NSFC) | China | 32170189 |
| National Natural Science Foundation of China (NSFC) | China | 32241021 |
| National Natural Science Foundation of China (NSFC) | China | 82341085 |
| Other government | 2022A1515110505 | |
| Other government | 2022M723164 |
Revision History (Full details and data files)
- Version 1.0: 2025-02-12
Type: Initial release
