Download MendeleyThe Crystal Structure of MAPK11 from Biortus.
Wang, F., Cheng, W., Yuan, Z., Lin, D., Guo, S.To be published.
8YGW
The Crystal Structure of MAPK11 from Biortus
- PDB DOI: https://doi.org/10.2210/pdb8YGW/pdb
- Classification: TRANSCRIPTION
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-02-27 Released: 2024-03-13
- Funding Organization(s): Not funded
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.30 ?
- R-Value Free: 0.278
- R-Value Work: 0.205
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Mitogen-activated protein kinase 11 | 364 | Homo sapiens | Mutation(s): 0 Gene Names: MAPK11, PRKM11, SAPK2, SAPK2B EC: 2.7.11.24 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q15759 (Homo sapiens) Explore Q15759 Go to UniProtKB: Q15759 | |||||
PHAROS: Q15759 GTEx: ENSG00000185386 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q15759 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| B96 (Subject of Investigation/LOI) Query on B96 | B [auth A] | 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA C31 H37 N5 O3 MVCOAUNKQVWQHZ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.30 ?
- R-Value Free: 0.278
- R-Value Work: 0.205
- Space Group: P 21 21 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 39.061 | ¦Á = 90 |
| b = 61.86 | ¦Â = 90 |
| c = 147.437 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| XDS | data reduction |
| Aimless | data scaling |
| PHASER | phasing |
