Download MendeleyDe novo design of TLR3 binders
Kim, H., Adams, C., Burtner, A., Lee, D.S., Dobbins, C., Criswell, C., Coventry, B., Kim, H.M., King, N.To be published.
8YHU
hTLR3/minibinder 8.6
- PDB DOI: https://doi.org/10.2210/pdb8YHU/pdb
- EM Map EMD-39301: EMDB EMDataResource
- Classification: DE NOVO PROTEIN
- Organism(s): Homo sapiens
- Expression System: Homo sapiens
- Mutation(s): No
- Deposited: 2024-02-28 Released: 2025-02-05
- Funding Organization(s): Other government
Experimental Data Snapshot
- Method: ELECTRON MICROSCOPY
- Resolution: 2.88 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Toll-like receptor 3 | 674 | Homo sapiens | Mutation(s): 0 Gene Names: TLR3 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for O15455 (Homo sapiens) Explore O15455 Go to UniProtKB: O15455 | |||||
PHAROS: O15455 GTEx: ENSG00000164342 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | O15455 | ||||
Glycosylation | |||||
| Glycosylation Sites: 10 | Go to GlyGen: O15455-1 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| minibinder 8.6 | 56 | Homo sapiens | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Oligosaccharides
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG Query on NAG | H [auth A], I [auth A], J [auth A], K [auth A], L [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: ELECTRON MICROSCOPY
- Resolution: 2.88 Å
- Aggregation State: PARTICLE
- Reconstruction Method: SINGLE PARTICLE
Entry History & Funding Information
Deposition Data
| Funding Organization | Location | Grant Number |
|---|---|---|
| Other government | -- |
Revision History (Full details and data files)
- Version 1.0: 2025-02-05
Type: Initial release
