Download MendeleyCrystal structure of chimeric hemagglutinin cH11/1 in complex with broad protective antibody 31.b.09
Nguyen, T.K.Y.To be published.
9C0X | pdb_00009c0x
Crystal structure of chimeric hemagglutinin cH11/1 in complex with broad protective antibody 31.b.09
- PDB DOI: https://doi.org/10.2210/pdb9C0X/pdb
- Classification: VIRAL PROTEIN/IMMUNE SYSTEM
- Organism(s): Influenza A virus, Homo sapiens
- Expression System: Trichoplusia ni, Cricetulus griseus
- Mutation(s): No
- Deposited: 2024-05-28 Released: 2025-05-07
- Funding Organization(s): National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 4.35 ?
- R-Value Free: 0.382 (Depositor), 0.410 (DCC)
- R-Value Work: 0.335 (Depositor), 0.350 (DCC)
- R-Value Observed: 0.337 (Depositor)
Starting Model: experimental
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This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hemagglutinin HA2 subunit | A [auth B] | 166 | Influenza A virus | Mutation(s): 0 Gene Names: HA |  |
UniProt | |||||
Find proteins for A0A6J3XB93 (Influenza A virus) Explore A0A6J3XB93 Go to UniProtKB: A0A6J3XB93 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | A0A6J3XB93 | ||||
Sequence AnnotationsExpand | |||||
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(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Antibody 31.b.09 Fab light chain | B [auth L] | 114 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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(by identity cutoff) | 3D Structure
Entity ID: 3 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Antibody 31.b.09 Fab heavy chain | C [auth H] | 121 | Homo sapiens | Mutation(s): 0 |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 4 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Hemagglutinin HA1 subunit | D [auth A] | 322 | Influenza A virus | Mutation(s): 0 Gene Names: HA |  |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Entity ID: 5 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Length | 2D Diagram | Glycosylation | 3D Interactions |
| 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | E [auth C] | 2 |  | N/A | |
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| NAG (Subject of Investigation/LOI) Query on NAG | F [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 4.35 ?
- R-Value Free: 0.382 (Depositor), 0.410 (DCC)
- R-Value Work: 0.335 (Depositor), 0.350 (DCC)
- R-Value Observed: 0.337 (Depositor)
Space Group: P 21 3
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 169.045 | ¦Á = 90 |
| b = 169.045 | ¦Â = 90 |
| c = 169.045 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data reduction |
| HKL-2000 | data scaling |
| PHENIX | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-05-07 Deposition Author(s): Nguyen, T.K.Y., Zhu, X., Wilson, I.A.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | United States | 75N93109C00051 |
Revision History (Full details and data files)
- Version 1.0: 2025-05-07
Type: Initial release
