Structural basis for ATP-triggered assembly of human mitochondrial Hsp60-Hsp10 chaperonin
Tascon, I., Lopez-Alonso, J.P., Ubarretxena-Belandia, I., Vilchez, J., Shkolnisky, Y., Azem, A., Hirsch, J.To be published.
Experimental Data Snapshot
Starting Model: experimental
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wwPDB Validation   3D Report Full Report
Entity ID: 1 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
60 kDa heat shock protein, mitochondrial | 549 | Homo sapiens | Mutation(s): 0  Gene Names: HSPD1, HSP60 EC: 3.6.4.9 (PDB Primary Data), 5.6.1.7 (UniProt) | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P10809 (Homo sapiens) Explore P10809  Go to UniProtKB:  P10809 | |||||
PHAROS:  P10809 GTEx:  ENSG00000144381  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P10809 | ||||
Sequence AnnotationsExpand | |||||
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Entity ID: 2 | |||||
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Molecule | Chains | Sequence Length | Organism | Details | Image |
10 kDa heat shock protein, mitochondrial | 102 | Homo sapiens | Mutation(s): 0  Gene Names: HSPE1 | ![]() | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P61604 (Homo sapiens) Explore P61604  Go to UniProtKB:  P61604 | |||||
PHAROS:  P61604 GTEx:  ENSG00000115541  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P61604 | ||||
Sequence AnnotationsExpand | |||||
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Ligands 3 Unique | |||||
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ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
ATP (Subject of Investigation/LOI) Query on ATP | AA [auth E] DA [auth F] GA [auth G] O [auth A] R [auth B] | ADENOSINE-5'-TRIPHOSPHATE C10 H16 N5 O13 P3 ZKHQWZAMYRWXGA-KQYNXXCUSA-N | |||
K Query on K | CA [auth E] FA [auth F] IA [auth G] Q [auth A] T [auth B] | POTASSIUM ION K NPYPAHLBTDXSSS-UHFFFAOYSA-N | |||
MG Query on MG | BA [auth E] EA [auth F] HA [auth G] P [auth A] S [auth B] | MAGNESIUM ION Mg JLVVSXFLKOJNIY-UHFFFAOYSA-N |
Task | Software Package | Version |
---|---|---|
MODEL REFINEMENT | PHENIX | 1.20.1 |
MODEL REFINEMENT | Coot | 0.9.1 |
RECONSTRUCTION | cryoSPARC | 3.3.1 |
Funding Organization | Location | Grant Number |
---|---|---|
United States - Israel Binational Science Foundation (BSF) | United States | -- |
Spanish Ministry of Science, Innovation, and Universities | Spain | -- |
Other government | Spain | -- |