5CDN

2.8A structure of etoposide with S.aureus DNA gyrase and DNA

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
I [auth R]	DNA_topoisoIV_1st	e5cdnR1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DNA_topoisoIV_1st	ECOD (1.6)
I [auth R]	DNA_topoisoIV_3rd	e5cdnR3	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: DNA_topoisoIV_3rd	ECOD (1.6)
I [auth R]	DNA_topoisoIV_2nd_1	e5cdnR2	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: DNA_topoisoIV_2nd_1	ECOD (1.6)
K [auth T]	DNA_topoisoIV_1st	e5cdnT2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DNA_topoisoIV_1st	ECOD (1.6)
K [auth T]	DNA_topoisoIV_3rd	e5cdnT3	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: DNA_topoisoIV_3rd	ECOD (1.6)
K [auth T]	DNA_topoisoIV_2nd_1	e5cdnT1	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: DNA_topoisoIV_2nd_1	ECOD (1.6)
A	DNA_topoisoIV_1st	e5cdnA3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DNA_topoisoIV_1st	ECOD (1.6)
A	DNA_topoisoIV_3rd	e5cdnA1	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: DNA_topoisoIV_3rd	ECOD (1.6)
A	DNA_topoisoIV_2nd_1	e5cdnA2	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: DNA_topoisoIV_2nd_1	ECOD (1.6)
C	DNA_topoisoIV_1st	e5cdnC2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: DNA_topoisoIV_1st	ECOD (1.6)
C	DNA_topoisoIV_3rd	e5cdnC3	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: DNA_topoisoIV_3rd	ECOD (1.6)
C	DNA_topoisoIV_2nd_1	e5cdnC1	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: DNA_topoisoIV_2nd_1	ECOD (1.6)
J [auth S]	DNA_gyraseB_C	e5cdnS1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: DNA_gyraseB_C	ECOD (1.6)
L [auth U]	DNA_gyraseB_C	e5cdnU1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: DNA_gyraseB_C	ECOD (1.6)
B	DNA_gyraseB_C	e5cdnB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: DNA_gyraseB_C	ECOD (1.6)
D	DNA_gyraseB_C	e5cdnD1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: DNA_gyraseB_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Provenance Source (Version)
J [auth S]	3.40.50.670	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	CATH (utative)
L [auth U]	3.40.50.670	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	CATH (utative)
B	3.40.50.670	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	CATH (utative)
D	3.40.50.670	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, I [auth R], K [auth T]	PF00521	DNA gyrase/topoisomerase IV, subunit A (DNA_topoisoIV)	DNA gyrase/topoisomerase IV, subunit A	-	Family
B, D, J [auth S], L [auth U]	PF00986	DNA gyrase B subunit, carboxyl terminus (DNA_gyraseB_C)	DNA gyrase B subunit, carboxyl terminus	-	Family
B, D, J [auth S], L [auth U]	PF01751	Toprim domain (Toprim)	Toprim domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, I [auth R], K [auth T]	DNA gyrase subunit A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding ATP-dependent activity, acting on DNA isomerase activity DNA negative supercoiling activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid DNA topoisomerase activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity catalytic activity ATP-dependent activity	response to stimulus response to chemical response to antibiotic nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization DNA conformation change response to stimulus response to chemical response to antibiotic nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization DNA conformation change cellular component organization DNA topological change organelle organization cellular component organization or biogenesis	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome cytoplasm
B, D, J [auth S], L [auth U]	DNA gyrase subunit B,DNA gyrase subunit B	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding ATP-dependent activity, acting on DNA isomerase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid DNA topoisomerase activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity catalytic activity ATP-dependent activity cation binding metal ion binding	nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization DNA conformation change cellular component organization DNA topological change organelle organization nucleobase-containing compound metabolic process DNA-templated DNA replication DNA replication metabolic process cellular process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process chromosome organization DNA conformation change cellular component organization DNA topological change organelle organization cellular component organization or biogenesis	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome cytoplasm
E, G [auth F], M [auth V], O [auth W]	DNA (5'-D(PGPAPGPCPGPTPAPGPGPCPCPGPTPAPCPGPCPTPC)-3')	-	-	-
F [auth G], H [auth O], N, P	DNA (5'-D(PGPAPGPCPGPTPAPCGPGPCPCPGPTPAPCPGPCPTPC)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, I [auth R], K [auth T]	IPR035516	DNA gyrase/topoisomerase IV, subunit A, C-terminal	Homologous Superfamily
A, C, I [auth R], K [auth T]	IPR050220	Type II DNA Topoisomerases	Family
A, C, I [auth R], K [auth T]	IPR013760	DNA topoisomerase, type IIA-like domain superfamily	Homologous Superfamily
A, C, I [auth R], K [auth T]	IPR013757	DNA topoisomerase, type IIA, alpha-helical domain superfamily	Homologous Superfamily
A, C, I [auth R], K [auth T]	IPR013758	DNA topoisomerase, type IIA, domain A, alpha-beta	Homologous Superfamily
A, C, I [auth R], K [auth T]	IPR005743	DNA gyrase, subunit A	Family
A, C, I [auth R], K [auth T]	IPR006691	DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat	Repeat
A, C, I [auth R], K [auth T]	IPR002205	DNA topoisomerase, type IIA, domain A	Domain
B, D, J [auth S], L [auth U]	IPR011557	DNA gyrase, subunit B	Family
B, D, J [auth S], L [auth U]	IPR034160	DNA gyrase subunit B, TOPRIM domain	Domain
B, D, J [auth S], L [auth U]	IPR018522	DNA topoisomerase, type IIA, conserved site	Conserved Site
B, D, J [auth S], L [auth U]	IPR013506	DNA topoisomerase, type IIA, subunit B, domain 2	Domain
B, D, J [auth S], L [auth U]	IPR013760	DNA topoisomerase, type IIA-like domain superfamily	Homologous Superfamily
B, D, J [auth S], L [auth U]	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
B, D, J [auth S], L [auth U]	IPR006171	TOPRIM domain	Domain
B, D, J [auth S], L [auth U]	IPR000565	DNA topoisomerase, type IIA, subunit B	Family
B, D, J [auth S], L [auth U]	IPR003594	Histidine kinase/HSP90-like ATPase domain	Domain
B, D, J [auth S], L [auth U]	IPR013759	DNA topoisomerase, type IIA, subunit B, C-terminal	Homologous Superfamily
B, D, J [auth S], L [auth U]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
B, D, J [auth S], L [auth U]	IPR001241	DNA topoisomerase, type IIA	Family
B, D, J [auth S], L [auth U]	IPR002288	DNA gyrase B subunit, C-terminal	Domain
B, D, J [auth S], L [auth U]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily