Download MendeleyMapping the binding surface of Cyclophilin A.
Mcnae, I.W., Dornan, D., Patterson, A.F., Wear, M.A., Blackburn, E.A., Walkinshaw, M.D.To be published.
4N1M
Structure of Cyclophilin A in complex with GlyPro.
- PDB DOI: https://doi.org/10.2210/pdb4N1M/pdb
- Classification: ISOMERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2013-10-04 Released: 2015-08-12
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.15 ?
- R-Value Free: 0.163
- R-Value Work: 0.134
- R-Value Observed: 0.135
wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Peptidyl-prolyl cis-trans isomerase A | 168 | Homo sapiens | Mutation(s): 0 Gene Names: PPIA, CYPA EC: 5.2.1.8 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P62937 (Homo sapiens) Explore P62937 Go to UniProtKB: P62937 | |||||
PHAROS: P62937 GTEx: ENSG00000196262 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P62937 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PRO Query on PRO | C [auth A] | PROLINE C5 H9 N O2 ONIBWKKTOPOVIA-BYPYZUCNSA-N |  | ||
| GLY Query on GLY | B [auth A] | GLYCINE C2 H5 N O2 DHMQDGOQFOQNFH-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.15 ?
- R-Value Free: 0.163
- R-Value Work: 0.134
- R-Value Observed: 0.135
- Space Group: P 21 21 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 40.46 | ¦Á = 90 |
| b = 52.3 | ¦Â = 90 |
| c = 90.33 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| ADSC | data collection |
| PHASER | phasing |
| REFMAC | refinement |
| MOSFLM | data reduction |
| SCALA | data scaling |
Entry History
Deposition Data
- Released Date: 2015-08-12 Deposition Author(s): Mcnae, I.W., Patterson, A., Walkinshaw, M.D.
Revision History (Full details and data files)
- Version 1.0: 2015-08-12
Type: Initial release - Version 1.1: 2024-02-28
Changes: Data collection, Database references, Derived calculations - Version 1.2: 2024-03-13
Changes: Source and taxonomy, Structure summary
