Download MendeleyComputationally designed tunable C2 symmetric tandem repeat homodimer, bound to cyclic peptide
Kennedy, M.A., Stoddard, B.L., Said, M.To be published.
8VX7
Computationally designed tunable C2 symmetric tandem repeat homodimer, bound to cyclic peptide
- PDB DOI: https://doi.org/10.2210/pdb8VX7/pdb
- Classification: DE NOVO PROTEIN
- Organism(s): synthetic construct
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2024-02-03 Released: 2025-02-05
- Funding Organization(s): National Science Foundation (NSF, United States), National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS), National Institutes of Health/National Institute on Aging (NIH/NIA)
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.75 ?
- R-Value Free: 0.299 (Depositor), 0.297 (DCC)
- R-Value Work: 0.253 (Depositor), 0.255 (DCC)
- R-Value Observed: 0.258 (Depositor)
wwPDB Validation 3D Report Full Report
This is version 1.0 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| CID7 | 162 | synthetic construct | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| MC1 | 8 | synthetic construct | Mutation(s): 0 |  | |
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Modified Residues 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| MEA Query on MEA | C | L-PEPTIDE LINKING | C10 H13 N O2 |  | PHE |
| MLE Query on MLE | C | L-PEPTIDE LINKING | C7 H15 N O2 |  | LEU |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.75 ?
- R-Value Free: 0.299 (Depositor), 0.297 (DCC)
- R-Value Work: 0.253 (Depositor), 0.255 (DCC)
- R-Value Observed: 0.258 (Depositor)
Space Group: P 21 21 21
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 33.434 | ¦Á = 90 |
| b = 79.802 | ¦Â = 90 |
| c = 105.939 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| PHENIX | refinement |
| HKL-2000 | data scaling |
| PHASER | phasing |
Entry History & Funding Information
Deposition Data
- Released Date: 2025-02-05 Deposition Author(s): Kennedy, M.A., Stoddard, B.L., Said, M.
| Funding Organization | Location | Grant Number |
|---|---|---|
| National Science Foundation (NSF, United States) | United States | DGE-1762114 |
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | R01GM115545 |
| National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | United States | R01GM139752 |
| National Institutes of Health/National Institute on Aging (NIH/NIA) | United States | R01AG063845 |
| National Institutes of Health/National Institute on Aging (NIH/NIA) | United States | U19AG065156 |
Revision History (Full details and data files)
- Version 1.0: 2025-02-05
Type: Initial release
