Download MendeleyStructure of the unphosphorylated C-terminal tail segment of the SRC kinase and its role in SRC activity regulation
Fleury, D., Sarubbi, E., Courjaud, A., Guitton, J.D., Ducruix, A.To be published.
1YI6
C-term tail segment of human tyrosine kinase (258-533)
- PDB DOI: https://doi.org/10.2210/pdb1YI6/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): Yes
- Deposited: 2005-01-11 Released: 2006-05-02
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 ?
- R-Value Free: 0.252
- R-Value Work: 0.216
- R-Value Observed: 0.216
Starting Model: experimental
View more details
wwPDB Validation 3D Report Full Report
This is version 1.5 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Proto-oncogene tyrosine-protein kinase Src | 276 | Homo sapiens | Mutation(s): 2 EC: 2.7.1.112 (PDB Primary Data), 2.7.10.2 (UniProt) |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P12931 (Homo sapiens) Explore P12931 Go to UniProtKB: P12931 | |||||
PHAROS: P12931 GTEx: ENSG00000197122 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P12931 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Modified Residues 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| PTR Query on PTR | A, B | L-PEPTIDE LINKING | C9 H12 N O6 P |  | TYR |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.00 ?
- R-Value Free: 0.252
- R-Value Work: 0.216
- R-Value Observed: 0.216
- Space Group: P 1 21 1
Unit Cell:
| Length ( ? ) | Angle ( ? ) |
|---|---|
| a = 66.985 | ¦Á = 90 |
| b = 63.421 | ¦Â = 109.54 |
| c = 76.693 | ¦Ă = 90 |
| Software Name | Purpose |
|---|---|
| DENZO | data reduction |
| SCALA | data scaling |
| AMoRE | phasing |
| CNS | refinement |
| CCP4 | data scaling |
Entry History
Deposition Data
- Released Date: 2006-05-02 Deposition Author(s): Fleury, D., Sarubbi, E., Courjaud, A., Guitton, J.D., Ducruix, A.
Revision History (Full details and data files)
- Version 1.0: 2006-05-02
Type: Initial release - Version 1.1: 2008-04-30
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2023-10-25
Changes: Data collection, Database references, Derived calculations, Refinement description - Version 1.4: 2023-11-15
Changes: Data collection - Version 1.5: 2024-10-30
Changes: Structure summary
